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1. (WO2014209474) MASS SPECTROMETRY ANALYSIS OF MICROORGANISMS IN SAMPLES

Pub. No.:    WO/2014/209474    International Application No.:    PCT/US2014/034767
Publication Date: Thu Jan 01 00:59:59 CET 2015 International Filing Date: Tue Apr 22 01:59:59 CEST 2014
IPC: H01J 49/02
H01J 49/26
B01D 59/44
Applicants: PURDUE RESEARCH FOUNDATION
Inventors: COOKS, Robert, Graham
HAMID, Ahmed, Mohamed
JARMUSCH, Alan, Keith
OUYANG, Zheng
Title: MASS SPECTROMETRY ANALYSIS OF MICROORGANISMS IN SAMPLES
Abstract:
The invention generally relates to systems and methods for mass spectrometry analysis of microorganisms in samples. Porous materials, such as filter paper or similar materials are used to hold and transfer liquids, and ions are generated directly from the edges of the materials when a high electric voltage is applied to the materials. The porous material is kept discrete (i.e., separate or disconnected from) from a flow of solvent. Instead, a sample is either spotted onto the porous material or the porous material is wetted and used to swab a surface containing the sample. The porous material with spotted or swabbed sample is then wetted and connected to a high voltage source to produce ions of the sample which are subsequently analyzed. The sample is transported through the porous material without the need of a separate solvent flow.