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1. (WO2014209096) NEW MONOCLONAL ANTIBODIES AGAINST THE RECEPTOR DEC-205 OF CHICKEN DENTRITIC CELLS

Pub. No.:    WO/2014/209096    International Application No.:    PCT/MX2014/000093
Publication Date: Thu Jan 01 00:59:59 CET 2015 International Filing Date: Wed Jun 18 01:59:59 CEST 2014
IPC: C07K 16/28
A61K 39/395
Applicants: UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO
Inventors: POSSANI POSTAY, Lourival Domingos
PEDRAZA ESCALONA, María Martha
ESPINO SOLIS, Geraldo Pavel
OLVERA RODRIGUEZ, Alejandro
CARDOSO TORRES, Héctor Miguel
Title: NEW MONOCLONAL ANTIBODIES AGAINST THE RECEPTOR DEC-205 OF CHICKEN DENTRITIC CELLS
Abstract:
The invention relates to the production and the characterisation of new murine monoclonal antibodies that recognise the domain CTDL-2 (SEQ ID NO: 1) of the cell receptor DEC-205 of dendritic cells in chickens (Gallus gallus), pigs, (Sus scrofa) and humans (Homo sapiens). The invention also relates to the capacity of the new antibodies to direct and modulate the immune response at different levels in chickens (Gallos gallus) and pigs (Sus scrofa), as well as recognising the receptor DEC-205 in dentritic cells and cell lines in humans. In addition, the invention is used to quickly produce a specific humoral immune response against Hemaglutinina H5 of the H5N2-type avian flu virus.