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1. (WO2014207888) BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERS

Pub. No.:    WO/2014/207888    International Application No.:    PCT/JP2013/067785
Publication Date: Thu Jan 01 00:59:59 CET 2015 International Filing Date: Sat Jun 29 01:59:59 CEST 2013
IPC: G01N 33/68
Applicants: MCBI INC.
株式会社MCBI
UNIVERSITY OF TSUKUBA
国立大学法人 筑波大学
Inventors: UCHIDA Kazuhiko
内田 和彦
MENO Kohji
目野 浩二
SUZUKI Hideaki
鈴木 秀昭
NISHIMURA Yoshinori
西村 吉典
Title: BIOMARKERS FOR COGNITIVE DYSFUNCTION DISEASES AND METHOD FOR DETECTING COGNITIVE DYSFUNCTION DISEASE USING BIOMARKERS
Abstract:
Provided are biomarkers for detecting cognitive dysfunction diseases and a method for detecting a cognitive dysfunction disease using the biomarker(s). The method for detecting a cognitive dysfunction disease which comprises simultaneously or separately measuring one or more kinds of biomarkers for detecting cognitive dysfunction diseases, said biomarkers being selected from (a), (b) and (c), in a biological sample: (a) a biomarker for detecting cognitive dysfunction diseases that comprises an intact protein of apolipoprotein A1 containing the amino acid sequence represented by SEQ ID NO:1 or a partial peptide thereof; (b) a biomarker for detecting cognitive dysfunction diseases that comprises an intact protein of transthyretin containing the amino acid sequence represented by SEQ ID NO:2 or a partial peptide thereof; and (c) a biomarker for detecting cognitive dysfunction diseases that comprises an intact protein of complement C3 containing the amino acid sequence represented by SEQ ID NO:3 or a partial peptide thereof.