The present invention includes systems, devices and methods for mechanically interfacing between a pump and an infusion kit or conduit, and methods and materials for producing same. According to some embodiments of the present invention, there may be provided a mechanical pump-tube interface unit adapted to detachably connect to a pump. The mechanical pump-tube interface unit may be adapted to hold a fluid conduit/tube positioned such that when the interface is attached to a pump the pumping mechanism of the pump acts upon the fluid in the tube. A mechanical pump-tube interface unit may include physical adaptations designed to prevent longitudal and/or rotational movement, in relation to the unit, of a fluid conduit/tube held by or attached to the interface unit. According to further embodiments, a segment of conduit/tube may be attached/connected to a mechanical tube-interface during the assembly of the interface unit, to form one integral unit including the conduit/tube segment secured/trapped within.