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1. (WO2014207311) THERAPEUTICALLY ACTIVE ESTRATRIENTHIAZOLE DERIVATIVES AS INHIBITORS OF 17.BETA.-HYDROXY-STEROID DEHYDROGENASE, TYPE 1

Pub. No.:    WO/2014/207311    International Application No.:    PCT/FI2014/050519
Publication Date: Thu Jan 01 00:59:59 CET 2015 International Filing Date: Thu Jun 26 01:59:59 CEST 2014
IPC: C07J 43/00
C07J 51/00
A61K 31/58
A61P 5/32
Applicants: FORENDO PHARMA LTD
Inventors: HIRVELÄ, Leena
KANGAS, Lauri
KOSKIMIES, Pasi
LAMMINTAUSTA, Risto
UNKILA, Mikko
Title: THERAPEUTICALLY ACTIVE ESTRATRIENTHIAZOLE DERIVATIVES AS INHIBITORS OF 17.BETA.-HYDROXY-STEROID DEHYDROGENASE, TYPE 1
Abstract:
The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R2, R3, R4, R7 and R8 are as defined in the claims. The invention further relates to their use as inhibitors of 17β-HSD1 and in treatment or prevention of steroid hormone dependent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17β-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the aforementioned compounds or pharmaceutically acceptable salts thereof.