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1. (WO2014207310) THERAPEUTICALLY ACTIVE 17-NITROGEN SUBSTITUTED ESTRATRIENTHIAZOLE DERIVATIVES AS INHIBITORS OF 17.BETA.-HYDROXYSTEROID DEHYDROGENASE

Pub. No.:    WO/2014/207310    International Application No.:    PCT/FI2014/050518
Publication Date: Thu Jan 01 00:59:59 CET 2015 International Filing Date: Thu Jun 26 01:59:59 CEST 2014
IPC: C07J 43/00
C07J 71/00
A61K 31/58
A61P 5/32
Applicants: FORENDO PHARMA LTD
Inventors: ELORANTA, Maire
HIRVELÄ, Leena
KANGAS, Lauri
KOSKIMIES, Pasi
LAMMINTAUSTA, Risto
UNKILA, Mikko
Title: THERAPEUTICALLY ACTIVE 17-NITROGEN SUBSTITUTED ESTRATRIENTHIAZOLE DERIVATIVES AS INHIBITORS OF 17.BETA.-HYDROXYSTEROID DEHYDROGENASE
Abstract:
The invention relates to compounds of formula (I) and pharmaceutically acceptable salts thereof wherein R2to R7are as defined in the claims. The invention further relates to their use as inhibitors of 17β-HSD and in treatment or prevention of steroid hormone de- pendent diseases or disorders, such as steroid hormone dependent diseases or disorders requiring the inhibition of the 17β-HSD1 enzyme and/or requiring the lowering of the endogenous estradiol concentration. The present invention also relates to the preparation of the aforementioned compounds and to pharmaceutical compositions comprising as an active ingredient(s) one or more of the afore- mentioned compounds or pharmaceutically acceptable salts thereof.