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1. (WO2014206866) STABLE INTRAVENOUS FORMULATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/206866    International Application No.:    PCT/EP2014/062982
Publication Date: 31.12.2014 International Filing Date: 20.06.2014
IPC:
A61K 9/00 (2006.01), A61K 47/02 (2006.01), A61K 47/18 (2006.01), A61K 47/26 (2006.01), A61K 9/08 (2006.01), A61K 9/19 (2006.01), A61K 31/40 (2006.01), A61P 35/00 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
HOFFMANN-LA ROCHE INC. [US/US]; 340 Kingsland Street Nutley, NJ 07110 (US) (US only)
Inventors: GALASSO, Anthony, N.; (US).
INBAR, Petra; (US).
QURESHI, Farooq; (US).
SAMPAT, Harendra, R.; (US).
ZHAN, Shangdong; (US)
Agent: BEYERMANN, Jochen; (CH)
Priority Data:
61/838,642 24.06.2013 US
61/840,930 28.06.2013 US
Title (EN) STABLE INTRAVENOUS FORMULATION
(FR) PRÉPARATION INTRAVEINEUSE STABLE
Abstract: front page image
(EN)A stable lyophilized formulation for intravenous administration of the compound 4-{[(2R, 3S, 5S)-4-(4-chloro-2-fluoro-phenyl)-3-(3- chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2- carbonyl]-amino}-3- methoxy -benzoic Acid l-[2-(2-methoxy-ethoxy)- ethoxycarbonyloxy]-ethyl ester is provided.
(FR)La présente invention concerne une préparation lyophilisée stable pour l'administration par voie intraveineuse du composé ester éthylique l-[2-(2-méthoxy-éthoxy)- éthoxycarbonyloxy] de l'acide 4-{[(2R, 3S, 5S)-4-(4-chloro-2-fluoro-phényl)-3-(3- chloro-2-fluoro-phényl)-4-cyano-5-(2,2-diméthyl-propyl)-pyrrolidine-2- carbonyl]-amino}-3-méthoxy benzoïque.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)