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1. (WO2014205393) NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/205393    International Application No.:    PCT/US2014/043484
Publication Date: 24.12.2014 International Filing Date: 20.06.2014
IPC:
C07D 403/06 (2006.01), C07D 249/08 (2006.01), A61K 31/4196 (2006.01), A61K 31/41 (2006.01), A61P 35/00 (2006.01), A61P 31/12 (2006.01)
Applicants: KARYOPHARM THERAPEUTICS INC. [US/US]; 85 Wells Avenue Newton, MA 02459 (US)
Inventors: BALOGLU, Erkan; (US).
SHACHAM, Sharon; (US).
MCCAULEY, Dilara; (US).
KASHYAP, Trinayan; (US).
SENAPEDIS, William; (US).
LANDESMAN, Yosef; (US).
GOLAN, Gali; (IL).
KALID, Ori; (IL).
SHECHTER, Sharon; (US)
Agent: ABELLEIRA, Susan, M.; (US)
Priority Data:
61/842,475 03.07.2013 US
61/838,129 21.06.2013 US
61/838,153 21.06.2013 US
61/838,135 21.06.2013 US
Title (EN) NUCLEAR TRANSPORT MODULATORS AND USES THEREOF
(FR) MODULATEURS DE TRANSPORT NUCLÉAIRE ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention relates to compounds of Structural Formulas (I), (II) and (III): or their pharmaceutically acceptable salts; pharmaceutical compositions comprising the compounds of Structural Formulas (I), (II) and (III); and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRMl activity. The values for the variables in Structural Formulas (I), (II) and (III) are as described and defined herein.
(FR)La présente invention concerne des composés de formules de structure (I), (II) et (III), ou leurs sels pharmaceutiquement acceptables; les compositions pharmaceutiques comprenant les composés de formules de structure (I), (II) et (III); et les procédés d'utilisation desdits composés, sels et compositions dans le traitement de divers troubles associés à l'activité de la CRM1. Les valeurs pour les variables dans les formules de structure (I), (II) et (III) sont comme décrites et définies ici.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)