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1. (WO2014205342) METHODS FOR TREATMENT OF OVARIAN CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/205342    International Application No.:    PCT/US2014/043402
Publication Date: 24.12.2014 International Filing Date: 20.06.2014
IPC:
C12N 5/07 (2010.01), C12N 5/16 (2006.01), G01N 33/574 (2006.01)
Applicants: MORPHOTEK, INC. [US/US]; 210 Welsh Pool Road Exton, PA 19341 (US)
Inventors: SCHWEIZER, Charles; (US).
O'SHANNESSY, Daniel, John; (US)
Agent: GROTH, Felicity, E.; (US)
Priority Data:
61/837,543 20.06.2013 US
Title (EN) METHODS FOR TREATMENT OF OVARIAN CANCER
(FR) PROCÉDÉ POUR LE TRAITEMENT D'UN CANCER DE L'OVAIRE
Abstract: front page image
(EN)Provided herein are methods of identifying a subpopulation of ovarian cancer patients who would be responsive to treatment regimens that target folate receptor alpha (FRA)- expressing ovarian tumors and methods of treatment of such patients using an anti-FRA therapeutic agent, such as an antigen-binding protein (e.g., antibody or antigen-binding fragment thereof) that specifically binds to FRA. Also provided are related kits for identification and treatment of the subpopulation of ovarian cancer patients.
(FR)La présente invention porte sur des procédés d'identification d'une sous-population de patientes atteintes de cancer de l'ovaire qui seraient sensibles à des régimes de traitement qui ciblent des tumeurs ovariennes exprimant le récepteur alpha aux folates (FRA) et sur des procédés de traitement de telles patientes utilisant un agent thérapeutique anti-FRA, tel qu'une protéine de liaison à l'antigène (par exemple un anticorps ou un fragment de liaison à l'antigène associé) qui se lie spécifiquement au FRA. L'invention porte également sur des trousses s'y rapportant pour l'identification et le traitement de la sous-population de patientes atteintes de cancer de l'ovaire.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)