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1. (WO2014205199) COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE RESPONSE, ENHANCING IMMUNOTHERAPY, AND INCREASING VACCINE POTENCY

Pub. No.:    WO/2014/205199    International Application No.:    PCT/US2014/043155
Publication Date: Thu Dec 25 00:59:59 CET 2014 International Filing Date: Fri Jun 20 01:59:59 CEST 2014
IPC: A01N 43/04
A01N 43/90
A61K 39/395
Applicants: NITOR THERAPEUTICS
BANTIA, Shanta
Inventors: BANTIA, Shanta
Title: COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE RESPONSE, ENHANCING IMMUNOTHERAPY, AND INCREASING VACCINE POTENCY
Abstract:
Compositions including at least one PNP inhibitor or at least one PNP inhibitor in combination with one or more agents identified as endogenous adjuvants useful for enhancing the potency of vaccine and cancer immunotherapies being administered for the prevention or treatment of infectious diseases or cancer. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits. Methods for increasing the levels of endogenous adjuvants to enhance the immunogenicity of an antigen as well as to augment the potency of vaccine and cancer immunotherapies are also disclosed.