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1. (WO2014205194) COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE RESPONSE FOR THE TREATMENT OF INFECTIOUS DISEASES AND CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/205194    International Application No.:    PCT/US2014/043141
Publication Date: 24.12.2014 International Filing Date: 19.06.2014
IPC:
A61K 31/519 (2006.01)
Applicants: NITOR THERAPEUTICS [US/US]; 689 Highland Lakes Cove Birmingham, AL 35242 (US).
BANTIA, Shanta [US/US]; (US)
Inventors: BANTIA, Shanta; (US)
Agent: EVERETT, Denise, M.; (US)
Priority Data:
61/838,252 22.06.2013 US
61/887,625 07.10.2013 US
61/934,094 31.01.2014 US
Title (EN) COMPOSITIONS AND METHODS FOR POTENTIATING IMMUNE RESPONSE FOR THE TREATMENT OF INFECTIOUS DISEASES AND CANCER
(FR) COMPOSITIONS ET MÉTHODES DE POTENTIALISATION DE LA RÉPONSE IMMUNITAIRE POUR LE TRAITEMENT DES MALADIES INFECTIEUSES ET DU CANCER
Abstract: front page image
(EN)Compositions and methods including at least one PNP inhibitor or at least one PNP inhibitor in combination with one or more agents identified as endogenous adjuvants useful in the treatment of pathogen infection and cancer are disclosed. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits. Methods for increasing levels of endogenous adjuvants to enhance an immune response and to potentiate/augment antiviral, antibacterial or anticancer effects of therapeutic agents are also disclosed.
(FR)L'invention concerne des compositions et des méthodes comprenant au moins un inhibiteur de la PNP ou au moins un inhibiteur de la PNP associé avec un ou plusieurs agents identifiés comme adjuvants endogènes servant au traitement des maladies infectieuses et du cancer. Les compositions peuvent se présenter sous forme de doses pharmaceutiques et les composants peuvent être assemblés comme des kits. L'invention concerne également des méthodes permettant d'augmenter les taux des adjuvants endogènes pour stimuler la réponse immunitaire et potentialiser/augmenter les effets antiviraux, antibactériens ou anticancéreux des agents thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)