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1. (WO2014205187) CYTOLETHAL DISTENDING TOXIN SUBUNIT B CONJUGATED OR FUSED TO BACILLUS ANTHRACIS TOXIN LETHAL FACTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/205187 International Application No.: PCT/US2014/043131
Publication Date: 24.12.2014 International Filing Date: 19.06.2014
IPC:
B82Y 5/00 (2011.01) ,C07K 14/32 (2006.01) ,C12N 15/62 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
5
Nano-biotechnology or nano-medicine, e.g. protein engineering or drug delivery
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
32
from Bacillus (G)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES[US/US]; Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, Maryland 20892-7660, US
Inventors: BACHRAN, Christopher H.; DE
LEPPLA, Stephen H.; US
Agent: LAWLEY, Stephanie M.; US
Priority Data:
61/837,42820.06.2013US
Title (EN) CYTOLETHAL DISTENDING TOXIN SUBUNIT B CONJUGATED OR FUSED TO BACILLUS ANTHRACIS TOXIN LETHAL FACTOR
(FR) SOUS-UNITÉ B DE TOXINE CYTOLÉTALE DISTENDANTE CONJUGUÉE OU FUSIONNÉE À UN FACTEUR LÉTAL DE TOXINE DE BACILLUS ANTHRACIS
Abstract:
(EN) Disclosed is a protein comprising a cytolethal distending toxin subunit B (CdtB) conjugated or fused to a Bacillus anthracis toxin lethal factor (LF) or a functional portion of LF. Related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of treating or preventing cancer, and methods of inhibiting the growth of a target cell are also disclosed.
(FR) L'invention porte sur une protéine comprenant une sous-unité B de toxine cytolétale distendante (CdtB) conjuguée ou fusionnée à un facteur létal de toxine (LF) de Bacillus anthracis ou une partie fonctionnelle de LF. L'invention porte également sur des molécules chimériques apparentées, ainsi que sur des acides nucléiques, des vecteurs d'expression recombinés, des cellules hôtes, des populations de cellules, des compositions pharmaceutiques, des procédés de traitement ou de prévention de cancer et des procédés d'inhibition de la croissance d'une cellule cible.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)