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1. (WO2014205109) COMPOSITIONS AND METHODS FOR THE TREATMENT AND MANAGEMENT OF STEATOSIS IN HUMAN LIVER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/205109 International Application No.: PCT/US2014/042997
Publication Date: 24.12.2014 International Filing Date: 18.06.2014
IPC:
A61K 48/00 (2006.01) ,C12N 15/11 (2006.01) ,C07D 493/04 (2006.01) ,C07D 401/14 (2006.01) ,C12Q 1/60 (2006.01)
Applicants: RUDEL, Lawrence, L.[US/US]; US
WAKE FOREST UNIVERSITY HEALTH SCIENCES[US/US]; 391 Technology Way, Suite 199 Winston-Salem, NC 27101, US
Inventors: RUDEL, Lawrence, L.; US
Agent: RIGAUT, Kathleen, D.; US
Priority Data:
61/836,40518.06.2013US
Title (EN) COMPOSITIONS AND METHODS FOR THE TREATMENT AND MANAGEMENT OF STEATOSIS IN HUMAN LIVER
(FR) COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT ET LA GESTION DE LA STÉATOSE DANS LE FOIE HUMAIN
Abstract:
(EN) Compositions and methods for the treatment and management of steatosis are disclosed. Specifically, the disclosure provides compositions and methods for the treatment and management of fatty liver disorders, particularly those associated with a lysosomal acid lipase (LAL) deficiency, by administration of an effective amount of a steroyl-O-acyltransferase inhibitor, the inhibitor being effective to reduce cholesterol ester accumulation.
(FR) L'invention concerne des compositions et des méthodes pour le traitement et la gestion de la stéatose.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)