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1. (WO2014204988) 5T4-TARGETED IMMUNOFUSION MOLECULE AND METHODS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/204988 International Application No.: PCT/US2014/042782
Publication Date: 24.12.2014 International Filing Date: 17.06.2014
IPC:
C07K 16/32 (2006.01) ,C12N 9/22 (2006.01) ,A61K 47/48 (2006.01) ,C07K 16/30 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
32
against translation products from oncogenes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
16
acting on ester bonds (3.1)
22
Ribonucleases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
Applicants:
ASANA BIOSCIENCES, LLC [US/US]; 400 Crossing Boulevard, Third Floor Bridgewater, NJ 08807-2863, US
Inventors:
DAMLE, Nitin; US
VENKATESAN, Aranapakam; US
KRISHNAN, Seetha; IN
PATTANAIK, Priyaranjan; IN
JOSHI, Saurabh; IN
Agent:
AKOPYAN, Nonna; US
Priority Data:
61/835,85817.06.2013US
Title (EN) 5T4-TARGETED IMMUNOFUSION MOLECULE AND METHODS
(FR) MOLÉCULE D'IMMUNOFUSION CIBLANT 5T4 ET PROCÉDÉS CORRESPONDANTS
Abstract:
(EN) Immunofusion molecules useful for 5T4-targeted therapy. The immunofusion molecules include the 5T4 antigen-binding portion of an anti-5T4 antibody engineered into a single chain form and fused to a cytotoxic payload, such as, human pancreatic RNase ("HPRN"). The RNase portion of the single immunofusion peptide may be fused to a polyglutamic acid (polyE) tail. A pharmaceutical composition includes an immunofusion molecule including a 5T4 antigen-binding portion and HPRN and methods of administering the composition to an animal in need.
(FR) L'invention porte sur des molécules d'immunofusion utiles pour une thérapie ciblant 5T4. Les molécules d'immunofusion comprennent la partie de liaison à l'antigène 5T4 d'un anticorps anti-5T4 génétiquement modifié en une forme monocaténaire, fusionnée à une charge cytotoxique, telle que la RNase pancréatique humaine (« HPRN »). La partie RNase de l'unique peptide d'immunofusion peut être fusionnée à une queue poly(acide glutamique) (polyE). L'invention porte également sur une composition pharmaceutique comprenant une molécule d'immunofusion comprenant une partie de liaison à l'antigène 5T4 et HPRN et sur des procédés d'administration de la composition à un animal qui en a besoin.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)