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1. (WO2014204861) UNIVERSAL METHYLATION PROFILING METHODS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/204861    International Application No.:    PCT/US2014/042567
Publication Date: 24.12.2014 International Filing Date: 16.06.2014
IPC:
C07H 19/23 (2006.01), C07H 19/167 (2006.01), C07H 19/173 (2006.01)
Applicants: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK [US/US]; West 116th Street and Broadway New York, NY 10027 (US) (For All Designated States Except US).
BESTOR, Timothy H. [US/US]; (US) (US only).
JU, Jingyue [US/US]; (US) (US only).
LI, Xiaoxu [CN/US]; (US) (US only)
Inventors: BESTOR, Timothy H.; (US).
JU, Jingyue; (US).
LI, Xiaoxu; (US)
Agent: WHITE, John P.; (US)
Priority Data:
61/836,060 17.06.2013 US
Title (EN) UNIVERSAL METHYLATION PROFILING METHODS
(FR) PROCÉDÉS UNIVERSELS DE PROFILAGE DE LA MÉTHYLATION
Abstract: front page image
(EN)The present invention provides a compound having the adenosylmethionine structure, wherein the sulfur atom of the methionine moiety is modified with alkene or succinimide groups, wherein R1, R2 and R3 are independently H, alkyl, aryl, C(0)NH2, C(0)R', CN, N02, C (O)R', S(0),NHR'; wherein X is 0 or NR'; wherein R' is H, alkyl or aryl; and wherein n is an integer from 1 to 8, with the proviso that, when substituent is a propene derivative, and n is 1, at least one of R1, R2, or R3 is other than H.
(FR)La présente invention concerne un composé de structure I : (I) dans laquelle R1, R2 et R3 représentent, indépendamment, H, un groupe alkyle, aryle, C(O)NH2, C(O)R', CN, NO2, S(O)2NHR' ; X représente O ou NR' ; R' représente H, un groupe alkyle ou aryle ; et n représente un nombre entier de 1 à 8, sous réserve que quand R représente II (II) et que n est égal à 1, au moins l'un des R1, R2 ou R3 est différent de H.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)