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1. (WO2014203918) METHOD OF PREDICTING THERAPEUTIC EFFECT OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS

Pub. No.:    WO/2014/203918    International Application No.:    PCT/JP2014/066100
Publication Date: Thu Dec 25 00:59:59 CET 2014 International Filing Date: Thu Jun 19 01:59:59 CEST 2014
IPC: G01N 33/53
C07K 14/71
G01N 33/574
Applicants: KURUME UNIVERSITY
学校法人 久留米大学
Inventors: AZUMA, Koichi
東 公一
HOSHINO, Tomoaki
星野 友昭
HATTORI, Satoshi
服部 聡
ITOH, Kyogo
伊東 恭悟
SASADA, Tetsuro
笹田 哲朗
KOMATSU, Nobukazu
小松 誠和
MATSUEDA, Satoko
松枝 智子
Title: METHOD OF PREDICTING THERAPEUTIC EFFECT OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITORS
Abstract:
The present invention provides a method of predicting the therapeutic effect of EGFR tyrosine kinase inhibitors, said method including the following steps: (1) measuring the quantity of antibodies against a peptide comprising an amino acid sequence selected from SEQ ID NO: 2-5 in a blood sample taken from a patient before treatment with an EGFR tyrosine kinase inhibitor; and (2) comparing the measured quantity of antibodies with a reference value, whereby the EGFR tyrosine kinase inhibitors are predicted to have a high therapeutic effect in the patient if the quantity of antibodies is higher than the reference value.