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1. (WO2014203691) NOVEL MEDICINE CONTAINING PLATINUM COMPLEX
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/203691 International Application No.: PCT/JP2014/063977
Publication Date: 24.12.2014 International Filing Date: 27.05.2014
IPC:
C07C 211/65 (2006.01) ,A61K 31/397 (2006.01) ,A61K 31/40 (2006.01) ,A61K 31/445 (2006.01) ,A61K 31/4465 (2006.01) ,A61K 31/4523 (2006.01) ,A61K 31/454 (2006.01) ,A61K 31/4545 (2006.01) ,A61K 31/4725 (2006.01) ,A61K 31/496 (2006.01) ,A61K 31/5377 (2006.01) ,A61K 31/541 (2006.01) ,A61P 35/00 (2006.01) ,C07D 205/04 (2006.01) ,C07D 207/16 (2006.01) ,C07D 211/62 (2006.01) ,C07D 401/06 (2006.01) ,C07F 15/00 (2006.01)
Applicants: TAKEUCHI, Yoshio[JP/JP]; JP
KABUSHIKI KAISHA YAKULT HONSHA[JP/JP]; 1-19, Higashi Shinbashi 1-chome, Minato-ku, Tokyo 1058660, JP
Inventors: TAKEUCHI, Yoshio; JP
YAEGASHI, Takashi; JP
NAGAOKA, Masato; JP
KONISHI, Hiroaki; JP
SUGIMOTO, Takuya; JP
NISHIYAMA, Hiroyuki; JP
TAKAGI, Akimitsu; JP
KOBAYASHI, Toshihide; JP
MATSUZAKI, Takeshi; JP
FUJIWARA, Tomoya; JP
Agent: THE PATENT CORPORATE BODY ARUGA PATENT OFFICE; Sawanotsuru Ningyocho Bldg., 1-3-8, Nihonbashi Ningyocho, Chuo-ku, Tokyo 1030013, JP
Priority Data:
2013-12792018.06.2013JP
Title (EN) NOVEL MEDICINE CONTAINING PLATINUM COMPLEX
(FR) NOUVEAU MÉDICAMENT CONTENANT UN COMPLEXE DU PLATINE
(JA) 白金錯体を含有する新規医薬
Abstract: front page image
(EN) Provided are a platinum complex that has an excellent antitumor effect and reduced toxicity such as myelosuppression, and a medicine containing the same. A platinum complex derivative represented by general formula (1) [wherein: R1 and R2 represent a hydrogen atom, or R1 and R2 together form a cycoalkanediyl group having 4 to 7 carbon atoms; A represents a carbon atom or CH-CH; m and n independently represent an integer of 1 or 2; and R3 represents a hydrogen atom, -COR4 or -SO2R4, wherein R4 represents an optionally substituted liner or branched alkyl group having 1 to 10 carbon atoms, an optionally substituted cycloalkyl group having 3 to 10 carbon atoms, or an optionally substituted aryl group having 6 to 12 carbon atoms].
(FR) L'invention porte sur un complexe du platine qui a un excellent effet antitumoral et une toxicité réduite telle que la myélosuppression, et sur un médicament le contenant. Le dérivé de complexe du platine selon l'invention est représenté par la formule générale (1) [dans laquelle : R1 et R2 représentent chacun un atome d'hydrogène ou R1 et R2 forment ensemble un groupe cycloalcanediyle ayant de 4 à 7 atomes de carbone ; A représente un atome de carbone ou CH-CH ; m et n représentent chacun indépendamment un nombre entier valant 1 ou 2 ; et R3 représente un atome d'hydrogène, -COR4 ou -SO2R4, où R4 représente un groupe alkyle linéaire ou ramifié éventuellement substitué ayant 1 à 10 atomes de carbone, un groupe cycloalkyle éventuellement substitué ayant 3 à 10 atomes de carbone ou un groupe aryle éventuellement substitué ayant 6 à 12 atomes de carbone].
(JA)  優れた抗腫瘍効果を有し、骨髄抑制等の毒性が軽減された白金錯体及びこれを含有する医薬の提供。 次の一般式(1) (式中、R1及びR2は、水素原子を示すか、又は一緒になって炭素数4~7のシクロアルカンジイル基を形成し; Aは炭素原子又はCH-CHを示し; m及びnはそれぞれ独立して1又は2の数を示し; R3は水素原子、-COR4又は-SO24を示し; R4は置換基を有していてもよい炭素数1~10の直鎖若しくは分岐鎖のアルキル基、置換基を有していてもよい炭素数3~10のシクロアルキル基、又は置換基を有していてもよい炭素数6~12のアリール基を示す) で表される白金錯体誘導体。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)