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1. (WO2014203204) CO-PRECIPITATION OF A THERAPEUTIC AGENT INTO HYDROXYAPATITE COATINGS

Pub. No.:    WO/2014/203204    International Application No.:    PCT/IB2014/062454
Publication Date: Thu Dec 25 00:59:59 CET 2014 International Filing Date: Fri Jun 20 01:59:59 CEST 2014
IPC: A61L 27/32
A61L 27/54
A61L 31/08
A61L 31/16
Applicants: STRYKER TRAUMA GMBH
Inventors: LILJA, Mirjam
SOERENSEN, Jan
PROCTER, Philip
STECKEL, Hartwig
SORENSEN, Torben
Title: CO-PRECIPITATION OF A THERAPEUTIC AGENT INTO HYDROXYAPATITE COATINGS
Abstract:
A method for co-precipitating a therapeutic agent into a hydroxyapatite coated surface includes the steps of providing a surface and applying a hydroxyapatite seed layer on the surface. The hydroxyapatite seed layered surface is contacted with a solution including the therapeutic agent and a co-precipitated therapeutic agent, hydroxyapatite layer is formed on the coated surface to uniformly distribute the therapeutic agent in the layer. Further, an implant having sustained therapeutic agent delivery includes a base and an hydroxyapatite seed layer disposed on a surface of the base. A co-precipitated hydroxyapatite coating is disposed on the seed layer. The coating includes a therapeutic agent, wherein the therapeutic agent is provided in a solution of therapeutic agent.