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1. (WO2014203189) NANOCARRIER SYSTEM FOR MICRORNAS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/203189    International Application No.:    PCT/IB2014/062389
Publication Date: 24.12.2014 International Filing Date: 18.06.2014
IPC:
A61K 47/48 (2006.01), A61P 35/00 (2006.01)
Applicants: ROSETTA GENOMICS LTD. [IL/IL]; 10 Plaut Street 7670609 Rehovot (IL).
RAMOT AT TEL-AVIV UNIVERSITY LTD. [IL/IL]; P.O. Box 39296 6139201 Tel Aviv (IL)
Inventors: YERUSHALMI, Noga; (IL).
KREDO-RUSSO, Sharon; (IL).
LITHWICK YANAI, Gila; (IL).
SATCHI-FAINARO, Ronit; (IL).
OFEK, Paula; (IL)
Agent: FEIGELSON, Daniel; 7 Oppenheimer St. 76701 Rehovot (IL)
Priority Data:
61/836,204 18.06.2013 US
Title (EN) NANOCARRIER SYSTEM FOR MICRORNAS AND USES THEREOF
(FR) SYSTÈME DE NANO-SUPPORT POUR MICRO-ARN ET SES UTILISATIONS
Abstract: front page image
(EN)Described herein are novel polyglycerol-amine polymeric nanocarriers in complex with microRNAs and their uses in the treatment of cancer, in particular glioblastoma. Delivery of the polymeric nanocarriers in complex with microRNAs in cell lines and in vivo inhibited cell proliferation, cell cycle progression, cell migration and tumor growth.
(FR)La présente invention concerne de nouveaux nano-supports polymères à base de polyglycérol-amine en complexe avec des micro-ARN, et leurs utilisations dans le traitement du cancer, en particulier du glioblastome. L'administration des nano-supports polymères en complexe avec des micro-ARN à des lignés cellulaires et in vivo a permis d'inhiber la prolifération cellulaire, la progression du cycle cellulaire, la migration cellulaire et la croissance des tumeurs.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)