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1. (WO2014203008) ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS

Pub. No.:    WO/2014/203008    International Application No.:    PCT/GB2014/051918
Publication Date: Thu Dec 25 00:59:59 CET 2014 International Filing Date: Tue Jun 24 01:59:59 CEST 2014
IPC: C12N 15/11
Applicants: UNIVERSITY OF GREENWICH
Inventors: RICHARDSON, Simon Clifford Wainwright
DYER, Paul Douglas Remane
MITCHELL, John Carlton
Title: ANTISENSE OLIGONUCLEOTIDE COMPOSITIONS
Abstract:
The present invention relates to antisense oligonucleotide (ASO) compositions and particularly to compositions and methods for the cytosolic delivery of antisense oligonucleotides (ASOs). Hybrid ASOs, part single-stranded and part double-stranded, are provided, hybridising to form a double-stranded region that can non-covalently bond to nucleic-acid-binding protein regions. In this way, ASO::protein complexes may be produced that facilitate delivery of antisense DNA into target cells. Such complexes may be used to down-regulate gene expression in cells.