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1. (WO2014202973) AGONISTS OF DDAH1 FOR TREATING ENDOTHELIAL DYSFUNCTION

Pub. No.:    WO/2014/202973    International Application No.:    PCT/GB2014/051867
Publication Date: Thu Dec 25 00:59:59 CET 2014 International Filing Date: Wed Jun 18 01:59:59 CEST 2014
IPC: A61K 31/713
C12Q 1/68
C12N 15/113
A61P 9/10
A61P 9/12
Applicants: UCL BUSINESS PLC
Inventors: MOOKERJEE, Rajeshwar
MEHTA, Gautam
Title: AGONISTS OF DDAH1 FOR TREATING ENDOTHELIAL DYSFUNCTION
Abstract:
The present invention derives from the finding that expression of DDAH1 is heavily post- transcriptionally regulated by microRNAs. By preventing or blocking the interaction between such microRNAs and the DDAH1 mRNA, the production of DDAH1 protein can be increased. This has utility in the prevention or treatment of diseases and disorders that are associated with reduced DDAH1 levels or increased ADMA levels, such as diseases or disorders that are characterised by endothelial dysfunction.