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1. (WO2014202834) PROTAMINE IN TREATMENT OF NEURONAL INJURIES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/202834    International Application No.:    PCT/FI2014/050491
Publication Date: 24.12.2014 International Filing Date: 18.06.2014
IPC:
A61K 38/16 (2006.01), A61K 38/17 (2006.01), C07K 14/435 (2006.01), A61P 25/00 (2006.01)
Applicants: UNIVERSITY OF HELSINKI [FI/FI]; Yliopistonkatu 4 FI-00014 University of Helsinki (FI)
Inventors: RAUVALA, Heikki; (FI).
PAVELIEV, Mikhail; (FI).
KUJA-PANULA, Juha; (FI).
ROUHIAINEN, Ari; (FI).
KULESSKAYA, Natalia; (FI)
Agent: KOLSTER OY AB; (Iso Roobertinkatu 23) P.O.Box 148 FI-00121 Helsinki (FI)
Priority Data:
20135667 18.06.2013 FI
Title (EN) PROTAMINE IN TREATMENT OF NEURONAL INJURIES
(FR) PROTAMINE POUR LE TRAITEMENT DE LÉSIONS NEURONALES
Abstract: front page image
(EN)The present invention relates to treatment of neuronal injury. The present invention discloses a novel use of an agent and a novel method for promoting neurite out growth and/or neural regeneration in CNS injuries. A novel mechanism of promoting neurite outgrowth by increasing the interaction of chondroitin sulphate proteoglycan (CSPG) to receptor protein tyrosine phosphatase sigma (RPTPσ) is disclosed.
(FR)La présente invention concerne le traitement d'une lésion neuronale. La présente invention concerne une nouvelle utilisation d'un agent et un nouveau procédé pour favoriser l'excroissance de neurites et/ou la régénération neurale dans des lésions du SNC. L'invention concerne un nouveau mécanisme pour favoriser l'excroissance de neurites par accroissement de l'interaction entre un protéoglycane sulfate de chondroïtine (CSPG) et un récepteur à activité protéine-tyrosine-phosphatase sigma (RPTPσ).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)