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1. (WO2014202765) PREPARATION OF CHIRAL 1-METHYL-2,3,4,5-1H-BENZODIAZEPINES VIA ASYMMETRIC REDUCTION OF ALPHA-SUBSTITUTED STYRENES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/202765    International Application No.:    PCT/EP2014/063048
Publication Date: 24.12.2014 International Filing Date: 20.06.2014
IPC:
C07D 223/16 (2006.01), C07C 67/03 (2006.01), C07C 69/635 (2006.01), C07C 201/12 (2006.01), C07C 205/09 (2006.01), C07C 209/34 (2006.01), C07C 209/48 (2006.01), C07C 211/29 (2006.01), C07C 217/40 (2006.01), C07C 233/18 (2006.01), C07C 253/30 (2006.01), C07C 255/10 (2006.01), C07C 311/17 (2006.01)
Applicants: LEK PHARMACEUTICALS D.D. [SI/SI]; Verovskova 57 1526 Ljubljana (SI)
Inventors: STAVBER, Gaj; (SI).
GAZIC SMILOVIC, Ivana; (SI).
CLUZEAU, Jerome; (SI).
RICHTER, Frank; (AT)
Agent: KLUSCHANZOFF, Harald; Industriestr. 25 83607 Holzkirchen (DE)
Priority Data:
13173237.2 21.06.2013 EP
Title (EN) PREPARATION OF CHIRAL 1-METHYL-2,3,4,5-1H-BENZODIAZEPINES VIA ASYMMETRIC REDUCTION OF ALPHA-SUBSTITUTED STYRENES
(FR) PRÉPARATION DE 1-MÉTHYL-2,3,4,5-1H-BENZODIAZÉPINES CHIRALES PAR RÉDUCTION ASYMÉTRIQUE DE STYRÈNES ALPHA-SUBST ITUÉS
Abstract: front page image
(EN)The present invention provides an asymmetric and economic synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine via novel intermediates applying an asymmetric enzymatic, biomimetic or catalytic reduction. The present invention also provides a novel green asymmetric catalytic reduction adapted for an aqueous medium to be applied in the synthesis of 8-chloro-1-methyl-2,3,4,5-tetrahydro-1 H-benzo[d]azepine or novel intermediates.
(FR)La présente invention concerne une synthèse asymétrique et économique de 8-chloro-1-méthyl-2,3,4,5-tétrahydro-1H-benzo[d]azépine par de nouveaux intermédiaires appliquant une réduction enzymatique, biomimétique ou catalytique asymétrique. La présente invention concerne également une nouvelle réduction catalytique asymétrique verte adaptée pour un milieu aqueux devant être appliqué dans la synthèse de 8-chloro-1-méthyl-2,3,4,5-tétrahydro-1H-benzo[d]azépine ou de nouveaux intermédiaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)