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1. (WO2014202717) PROCESS FOR THE PREPARATION OF FROVATRIPTAN AND ITS ENANTIOMER
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/202717 International Application No.: PCT/EP2014/062937
Publication Date: 24.12.2014 International Filing Date: 19.06.2014
IPC:
C07D 209/88 (2006.01)
Applicants: DUKE CHEM, S.A.[ES/ES]; Av. Mare de Déu de Montserrat, 93-99, Pol. Ind. Sant Pere Molanta E-08799 Olèrdola, ES
Inventors: SILVA GUISASOLA, Octavio; ES
ESTEVE CASOL, Judit; ES
Agent: ZBM PATENTS - ZEA, BARLOCCI & MARKVARDSEN; Pl. Catalunya, 1 2nd floor ES-08002 Barcelona, ES
Priority Data:
13382233.820.06.2013EP
Title (EN) PROCESS FOR THE PREPARATION OF FROVATRIPTAN AND ITS ENANTIOMER
(FR) PROCÉDÉ DE PRÉPARATION DU FROVATRIPTAN ET DE SON ÉNANTIOMÈRE
Abstract: front page image
(EN) Process for the preparation of frovatriptan and its enantiomer It relates to the compounds of formula [II-(R,S)] and formula [II-(S,R)], and to a process for their preparation which comprises: a) reacting an enantiomeric mixture containing a compound of formula [I-(R)] and a compound of formula [I-(S)] with a chiral agent in the presence of a solventmixture; b) isolating the compound of formula [II-(R,S)] or, alternatively, the compound of formula [II-(S,R)] from the corresponding diastereomericmixture; and c) optionally purifying them. It also relates to a process for the preparation of frovatriptan and its enantiomer from a compound of formula [II-(R,S)] or a compound of formula [II-(S,R)] respectively.
(FR) Cette invention concerne un procédé de préparation du frovatriptan et de son énantiomère, en particulier, les composés de formule [II-(R,S)] et de formule [II-(S,R)], et leur procédé de préparation qui comprend : a) la réaction d'un mélange d'énantiomères contenant un composé de formule [I-(R)] et un composé de formule [I-(S)] avec un agent chiral en présence d'un mélange de solvants ; b) l'isolement du composé de formule [II-(R,S)] ou, alternativement, du composé de formule [II-(S,R)] du mélange de diastéréomères correspondant ; et c) éventuellement leur purification. Un procédé de préparation du frovatriptan et de son énantiomère à partir d'un composé de formule [II-(R,S)] ou d'un composé de formule [II-(S,R)], respectivement, est en outre décrit.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)