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1. (WO2014202697) NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/202697    International Application No.:    PCT/EP2014/062896
Publication Date: 24.12.2014 International Filing Date: 18.06.2014
IPC:
C07D 273/00 (2006.01), C07D 279/22 (2006.01), C07D 413/04 (2006.01), A61K 31/395 (2006.01), A61P 31/10 (2006.01), A61P 11/06 (2006.01)
Applicants: CYGNET BIOSCIENCES B.V. [--/NL]; Landhuis Joonchi Kaya Richard J. Beaujon z/n Willemstad (CW)
Inventors: SANFILIPPO, Stefania; (IT).
POSTERARO, Brunella; (IT).
SANGUINETTI, Maurizio; (IT).
BOTTA, Maurizio; (IT).
MACCARI, Giorgio; (IT).
DE LUCA, Filomena; (IT).
DOCQUIER, Jean-Denis; (IT).
DEODATO, Davide; (IT)
Agent: CAPASSO, Olga; De Simone & Partners S.p.A. Via V. Bellini 20 I-00198 Roma (IT)
Priority Data:
61/836,401 18.06.2013 US
Title (EN) NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS
(FR) NOUVEAUX DÉRIVÉS AMIDINOUREA MACROCYCLIQUES, PROCÉDÉS DE PRÉPARATION ET D'UTILISATION DE CEUX-CI EN TANT QU'INHIBITEURS DE CHITINASES.
Abstract: front page image
(EN)The present invention relates to macrocyclic amidinourea derivatives of formula 8, methods of preparation and uses thereof, pharmaceutical compositions in particular to be used as chitinase inhibitors in the treatment of a fungal infection.
(FR)La présente invention concerne des dérivés amidinourea macrocycliques représentés par la formule 8, des procédés de préparation et d'utilisation de ceux-ci, des compositions pharmaceutiques utilisables en particulier en tant qu'inhibiteurs de chitinases pour le traitement d'une infection fongique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)