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1. (WO2014202697) NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS

Pub. No.:    WO/2014/202697    International Application No.:    PCT/EP2014/062896
Publication Date: Thu Dec 25 00:59:59 CET 2014 International Filing Date: Thu Jun 19 01:59:59 CEST 2014
IPC: C07D 273/00
C07D 279/22
C07D 413/04
A61K 31/395
A61P 31/10
A61P 11/06
Applicants: CYGNET BIOSCIENCES B.V.
Inventors: SANFILIPPO, Stefania
POSTERARO, Brunella
SANGUINETTI, Maurizio
BOTTA, Maurizio
MACCARI, Giorgio
DE LUCA, Filomena
DOCQUIER, Jean-Denis
DEODATO, Davide
Title: NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS
Abstract:
The present invention relates to macrocyclic amidinourea derivatives of formula 8, methods of preparation and uses thereof, pharmaceutical compositions in particular to be used as chitinase inhibitors in the treatment of a fungal infection.