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1. (WO2014202659) PROCESS FOR THE PREPARATION OF AMIDES OF N-[1-(S)-(ETHOXYCARBONYL)-3-PHENYLPROPYL]-L-ALANINE

Pub. No.:    WO/2014/202659    International Application No.:    PCT/EP2014/062814
Publication Date: Thu Dec 25 00:59:59 CET 2014 International Filing Date: Thu Jun 19 01:59:59 CEST 2014
IPC: C07D 217/26
C07D 207/12
C07D 209/12
C07D 209/52
Applicants: SANOFI-AVENTIS DEUTSCHLAND GMBH
Inventors: KRETZSCHMAR, Gerhard
ROSSEN, Kai
Title: PROCESS FOR THE PREPARATION OF AMIDES OF N-[1-(S)-(ETHOXYCARBONYL)-3-PHENYLPROPYL]-L-ALANINE
Abstract:
A process for the production of amides of N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine is described. The process can be used for the production of key intermediates and finally the ACE inhibitors such as Ramipril, Enalapril, Quinapril, Trandolapril, Delapril and Moexipril starting from N-[1-(S)-(ethoxycarbonyl)-3-phenylpropyl]-L-alanine by the reaction with the appropriate amines.