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1. (WO2014201856) DASATINIB AND NONLINEAR CONFIGURATION POLYETHYLENE GLYCOL CONJUGATE

Pub. No.:    WO/2014/201856    International Application No.:    PCT/CN2014/000599
Publication Date: Thu Dec 25 00:59:59 CET 2014 International Filing Date: Thu Jun 19 01:59:59 CEST 2014
IPC: A61K 47/48
A61K 31/506
A61P 35/00
A61P 35/02
Applicants: JENKEM TECHNOLOGY CO., LTD. (TIANJIN)
天津键凯科技有限公司
Inventors: WANG, Jinliang
汪进良
ZHAO, Xuan
赵宣
WANG, Zhenguo
王振国
Title: DASATINIB AND NONLINEAR CONFIGURATION POLYETHYLENE GLYCOL CONJUGATE
Abstract:
A dasatinib and nonlinear configuration polyethylene glycol conjugate represented by formula I, wherein core is the core structure of a nonlinear configuration of polyethylene glycol, selected from a residue of pentaerythritol, methylglucoside, sucrose, diethylene glycol, propanediol, glycerol or polyglycerol, after removal of a hydrogen atom from the hydroxyl group; P is a polyethylene glycol residue with a number-average molecular weight of 300-60000 Da; X is a single bond, –CH2CO-, -CH2CH2OCO- or CH2CH2NHCO-; and i is 3, 4, 6 or 8.