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1. (WO2014201856) DASATINIB AND NONLINEAR CONFIGURATION POLYETHYLENE GLYCOL CONJUGATE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/201856    International Application No.:    PCT/CN2014/000599
Publication Date: 24.12.2014 International Filing Date: 18.06.2014
IPC:
A61K 47/48 (2006.01), A61K 31/506 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01)
Applicants: JENKEM TECHNOLOGY CO., LTD. (TIANJIN) [CN/CN]; Room 502-503, Building B, No.5 Disi Street, Development Zone Tianjin 300457 (CN)
Inventors: WANG, Jinliang; (CN).
ZHAO, Xuan; (CN).
WANG, Zhenguo; (CN)
Agent: BEIJING ARETE INTELLECTUAL PROPERTY AGENCY; (CN)
Priority Data:
201310241908.7 18.06.2013 CN
Title (EN) DASATINIB AND NONLINEAR CONFIGURATION POLYETHYLENE GLYCOL CONJUGATE
(FR) CONJUGUÉ DE DASATINIB ET DE POLYÉTHYLÈNE GLYCOL À CONFIGURATION NON LINÉAIRE
(ZH) 达沙替尼与非线性构型聚乙二醇的结合物
Abstract: front page image
(EN)A dasatinib and nonlinear configuration polyethylene glycol conjugate represented by formula I, wherein core is the core structure of a nonlinear configuration of polyethylene glycol, selected from a residue of pentaerythritol, methylglucoside, sucrose, diethylene glycol, propanediol, glycerol or polyglycerol, after removal of a hydrogen atom from the hydroxyl group; P is a polyethylene glycol residue with a number-average molecular weight of 300-60000 Da; X is a single bond, –CH2CO-, -CH2CH2OCO- or CH2CH2NHCO-; and i is 3, 4, 6 or 8.
(FR)La présente invention concerne un conjugué de dasatinib et de polyéthylène glycol à configuration non linéaire de formule I, dans laquelle « Core » est la structure de base d'une configuration non linéaire de polyéthylène glycol, choisie parmi un résidu pentaérythritol, méthylglucoside, sucrose, diéthylène glycol, propanediol, glycérol ou polyglycérol, après élimination d'un atome d'hydrogène du groupe hydroxyle; P est un résidu polyéthylène glycol ayant une masse moléculaire moyenne en nombre de 300 à 60000 Da; X est une liaison simple, –CH2CO-, -CH2CH2OCO- ou CH2CH2NHCO-; et i vaut 3, 4, 6 ou 8.
(ZH)一种达沙替尼与非线性构型聚乙二醇形成的如通式I所示的结合物,其中core为非线性构型聚乙二醇的核心结构,选自季戊四醇、甲基葡萄糖苷、蔗糖、二甘醇、丙二醇、甘油或据甘油的羟基去除氢的残基;P为数均分子量为300-60000道尔顿的聚乙二醇类残基;X为单键、—CH2CO—、—CH2CH2OCO—或—CH2CH2NHCO—;并且i为3,4,6或8。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)