WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2014201587) SUBSTANCE HAVING TYROSINE KINASE INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/201587    International Application No.:    PCT/CN2013/000720
Publication Date: 24.12.2014 International Filing Date: 20.06.2013
IPC:
C07D 209/34 (2006.01), C07D 403/12 (2006.01), A61K 31/404 (2006.01), A61K 31/4184 (2006.01), A61P 35/00 (2006.01)
Applicants: INSTITUTE OF RADIATION MEDICINE,CHINA ACADEMY OF MILITARY MEDICAL SCIENCES PLA [CN/CN]; Taiping Road 27, Haidian District Beijing 100850 (CN)
Inventors: YANG, Xiaoming; (CN).
WANG, Lin; (CN).
LI, Changyan; (CN).
ZHAN, Yiqun; (CN).
LIU, Jing; (CN).
LUO, Teng; (CN).
YAN, Haiyan; (CN).
ZHANG, Shouguo; (CN).
LI, Wei; (CN).
WEN, Xiaoxue; (CN).
PENG, Tao; (CN).
LI, Lu; (CN)
Agent: SHANGCHENG&PARTNERS; 18th Floor, Ever Bright World Center No.28 West Ping An Li Avenue Xicheng District, Beijing 100034 (CN)
Priority Data:
Title (EN) SUBSTANCE HAVING TYROSINE KINASE INHIBITORY ACTIVITY AND PREPARATION METHOD AND USE THEREOF
(FR) SUBSTANCE POSSÉDANT UNE ACTIVITÉ INHIBITRICE DES TYROSINE KINASES, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 具有酪氨酸激酶抑制活性的物质、其制备方法及用途
Abstract: front page image
(EN)Disclosed in the invention are a substance having tyrosine kinase inhibitory activity and a preparation method and use thereof, wherein the substance is a compound having the structure of general formula (I) or the geometrical isomer and medicinal salt thereof. The invention, through tyrosine kinase inhibitory activity evaluation and related experiments, confirms that these compounds have a good tyrosine kinase inhibitory activity, and can inhibit a variety of tumour cells, and it can be developed into drugs for preventing and treating tumorous diseases, especially resisting liver cancer, lung cancer and neuroblastoma.
(FR)La présente invention concerne une substance possédant une activité inhibitrice des tyrosine kinases ainsi que son procédé de préparation et son utilisation, ladite substance étant un composé ayant la structure de formule générale (I) ou son isomère géométrique ou l'un de ses sels médicinaux. L'invention, par l'évaluation de l'activité inhibitrice des tyrosine kinases et des expériences associées, confirme que ce composé possède une bonne activité inhibitrice des tyrosine kinases et peut inhiber diverses cellules tumorales. Ladite substance peut donc être développée en médicaments pour la prévention et le traitement de maladies tumorales, spécialement un cancer du foie, un cancer du poumon et un neuroblastome résistants.
(ZH)本发明公开一种具有酪氨酸激酶抑制活性的物质、其制备方法及用途,该物质为具有通式I结构的化合物、其几何异构体及其药用盐。本发明通过酪氨酸激酶抑制活性评价及相关实验,确证这些化合物具有良好的酪氨酸激酶抑制活性,能抑制多种肿瘤细胞,可开发为防治肿瘤疾病,特别是抗肝癌、肺癌和神经母细胞瘤的药物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)