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1. (WO2014201454) DNAZYME-NANOPARTICLE CONJUGATES AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/201454 International Application No.: PCT/US2014/042480
Publication Date: 18.12.2014 International Filing Date: 16.06.2014
IPC:
A61K 39/12 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
Applicants: CARTER, James R.[US/US]; US
FRASER, Malcolm J.[US/US]; US
UNIVERSITY OF NOTRE DAME[US/US]; 940 Grace Hall Notre Dame, Indiana 46556, US
Inventors: CARTER, James R.; US
FRASER, Malcolm J.; US
Agent: LUCKOW, Verne A.; US
Priority Data:
61/835,17314.06.2013US
61/835,75817.06.2013US
Title (EN) DNAZYME-NANOPARTICLE CONJUGATES AND METHODS OF USE THEREOF
(FR) CONJUGUÉS ADNZYME-NANOPARTICULE ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) The present invention relates to DNAzymes (also known as deoxyribozymes, DNA enzymes, catalytic DNA, or DZ), which are conjugated to nanoparticles (NP) to facilitate the detection of nucleic acids. One aspect of the invention relates to compounds comprising DNAzymes conjugated to nanoparticles (DZ-NP), such as metallic or gold nanoparticles, and methods for their synthesis. Another aspect of the invention relates to methods of using the conjugated compounds to detect nucleic acids, such as genomic material or transcripts of infectious agents, such as viruses, exemplified by applications demonstrating visual detection of Flavivirus RNA molecules, such as dengue virus, or Alphavirus RNA molecules, such as chikungunya virus, in short time periods, using compositions comprising stable components.
(FR) La présente invention concerne les ADNzymes (aussi connus sous le nom de déoxyribozyme, ADN enzyme, ADN catalytique, ou DZ) qui sont conjugués avec des nanoparticules (NP) pour faciliter la détection d'acides nucléiques. Un aspect de l'invention concerne des composés comportant des ADNzymes conjugués avec des nanoparticules (DZ-NP), tels que des nanoparticules métalliques ou d'or, ainsi que des méthodes pour leur synthèse. Un autre aspect de l'invention concerne des procédés d'utilisation des composés conjugués pour détecter des acides nucléiques, tels que du matériel génomique ou des transcriptions d'agents infectieux, tels que des virus, par exemple des applications montrant la détection visuelle de molécules ARN de flavivirus, tel que le virus de la dengue, ou des molécules ARN d'alphavirus, tel que le virus du chikungunya, dans des courtes périodes de temps, en utilisant des compositions comportant des constituants stables.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)