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1. (WO2014201111) TREATMENT OF MTOR HYPERACTIVE RELATED DISEASES AND DISORDERS

Pub. No.:    WO/2014/201111    International Application No.:    PCT/US2014/041902
Publication Date: Fri Dec 19 00:59:59 CET 2014 International Filing Date: Thu Jun 12 01:59:59 CEST 2014
IPC: C07C 229/00
Applicants: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
Inventors: HENSKE, Elizabeth P.
MEDVETZ, Douglas A.
Title: TREATMENT OF MTOR HYPERACTIVE RELATED DISEASES AND DISORDERS
Abstract:
Embodiments disclosed herein provide compositions and methods for treating cancer having deregulated mTOR signaling or mTOR hyperactivity, e.g., lymphangioleiomyomatosis (LAM), LAM/TSC or treating and/or management of tuberous sclerosis complex (TSC). Such methods and compositions comprise at least one compound selected from the group consisting of nateglinide, Z-L-Phe chloromethyl ketone, clemastine fumarate, supercinnamaldehyde, practolol, fluvastatin Na, sulindac, BIO, amorolfine, spectinomucin, sibutramine HCl, nelfinavir mesylate, moroxydine HCl, nicotine ditartrate, trequinsin, meglumine, tizanidine HCl, CGP-74514A hydrochloride, tioconazole, TOVOK™ (afatinib), or kasugamycin.