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1. (WO2014201016) INHIBITORS OF THE MITF MOLECULAR PATHWAY
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/201016 International Application No.: PCT/US2014/041730
Publication Date: 18.12.2014 International Filing Date: 10.06.2014
IPC:
A61K 31/12 (2006.01) ,A61K 31/135 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
Applicants: THE GENERAL HOSPITAL CORPORATION[US/US]; 55 Fruit Street Boston, Massachusetts 02114, US
THE BROAD INSTITUTE[US/US]; 7 Cambridge Center Cambridge, Massachusetts 02142, US
UNIVERSITY OF KANSAS[US/US]; 245 Strong Hall 1450 Jayhawk Boulevard Lawrence, Kansas 66045, US
Inventors: FALOON, Patrick; US
WEINER, Warren S.; US
SMITH, Robert A.; US
SCHOENEN, Frank John; US
FISHER, David E.; US
HAQ, Rizwan; US
Agent: RESNICK, David S.; US
Priority Data:
61/833,19210.06.2013US
Title (EN) INHIBITORS OF THE MITF MOLECULAR PATHWAY
(FR) INHIBITEURS DE LA VOIE MOLÉCULAIRE MITF
Abstract:
(EN) Provided herein are compounds of the formula (IV) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful as MITF inhibitors, MITF pathway inhibitors and for the treatment of cancer.
(FR) La présente invention concerne des composés de formule (IV) ainsi que leurs sels pharmaceutiquement acceptables, la signification des substituants de la formule étant indiquée dans la description. Ces composés, et les compositions pharmaceutiques les contenant, sont utiles comme inhibiteurs de MITF, inhibiteurs de la voie MITF et pour le traitement du cancer.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)