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Machine translation
1. (WO2014201015) METHODS AND COMPOSITIONS FOR TARGET DNA MODIFICATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/201015    International Application No.:    PCT/US2014/041728
Publication Date: 18.12.2014 International Filing Date: 10.06.2014
IPC:
C12N 15/00 (2006.01), C12N 15/87 (2006.01), C07K 14/00 (2006.01), C07H 21/04 (2006.01), A01K 67/00 (2006.01)
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, California 94607 (US)
Inventors: KOSHLAND, Douglas E.; (US).
WAHBA, Lamia; (US)
Agent: BORDEN, Paula A.; Bozicevic, Field & Francis LLP. 1900 University Avenue, Suite 200 East Palo Alto, California 94303 (US)
Priority Data:
61/833,798 11.06.2013 US
Title (EN) METHODS AND COMPOSITIONS FOR TARGET DNA MODIFICATION
(FR) MÉTHODES ET COMPOSITIONS POUR LA MODIFICATION D'ADN CIBLE
Abstract: front page image
(EN)The disclosure provides compositions and methods for increasing efficiency of Cas9-mediated target DNA modification. Specifically, the disclosure provides compositions and methods for carrying out site-directed modification of a target DNA, the methods comprising contacting the target DNA with: a) a complex comprising a Cas9 polypeptide and a guide RNA, and b) a Rad51 polypeptide. The site-directed modification of a target DNA can be carried out in a living cell in vitro, in a living cell in vivo, or in a cell-free system in vitro.
(FR)La présente invention concerne des compositions et des méthodes qui permettent d'augmenter l'efficacité de modification d'ADN cible à médiation assurée par Cas9.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)