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Machine translation
1. (WO2014200557) METHOD OF INCREASING THE AMOUNT OF FETAL HEMOGLOBIN IN A CELL AND/OR MAMMAL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/200557    International Application No.:    PCT/US2013/067811
Publication Date: 18.12.2014 International Filing Date: 31.10.2013
IPC:
C12N 15/867 (2006.01), A61K 48/00 (2006.01), A61P 7/00 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 Bethesda, Maryland 20892-7660 (US)
Inventors: MILLER, Jeffery L.; (US).
MULJO, Stefan A.; (US).
LEE, Yuanwei T.; (US).
DE VASCONCELLOS, Jaira Ferreira; (US).
BYRNES, Colleen; (US)
Agent: SPENNER, Jonathan M.; LEYDIG, VOIT & MAYER, LTD. Two Prudential Plaza, Suite 4900 180 North Stetson Avenue Chicago, Illinois 60601 (US)
Priority Data:
61/833,275 10.06.2013 US
61/837,840 21.06.2013 US
Title (EN) METHOD OF INCREASING THE AMOUNT OF FETAL HEMOGLOBIN IN A CELL AND/OR MAMMAL
(FR) PROCÉDÉ POUR AUGMENTER LA QUANTITÉ D'HÉMOGLOBINE FŒTALE DANS UNE CELLULE ET/OU CHEZ UN MAMMIFÈRE
Abstract: front page image
(EN)In embodiments of the invention, the invention provides a method of increasing the amount of fetal hemoglobin or decreasing the amount of adult hemoglobin in a cell. In other embodiments of the invention, the invention provides a method of preventing or treating sickle cell disease or a β-thalassemia in a mammal. In another embodiment of the invention, the invention provides plasmids encoding the protein LIN28A, the protein LIN28B, a let-7 sponge, or any combination thereof.
(FR)Dans certains modes de réalisation, l'invention concerne un procédé pour augmenter la quantité d'hémoglobine fœtale ou pour diminuer l'hémoglobine adulte dans une cellule. Dans d'autres, l'invention concerne un procédé pour prévenir ou traiter la drépanocytose ou la β-thalassémie chez un mammifère. Des plasmides codant pour la protéine LIN28A, la protéine LIN28B, une éponge let-7, ou l'une quelconque de leurs combinaisons, sont en outre décrits.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)