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1. (WO2014200557) METHOD OF INCREASING THE AMOUNT OF FETAL HEMOGLOBIN IN A CELL AND/OR MAMMAL

Pub. No.:    WO/2014/200557    International Application No.:    PCT/US2013/067811
Publication Date: Fri Dec 19 00:59:59 CET 2014 International Filing Date: Fri Nov 01 00:59:59 CET 2013
IPC: C12N 15/867
A61K 48/00
A61P 7/00
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
Inventors: MILLER, Jeffery L.
MULJO, Stefan A.
LEE, Yuanwei T.
DE VASCONCELLOS, Jaira Ferreira
BYRNES, Colleen
Title: METHOD OF INCREASING THE AMOUNT OF FETAL HEMOGLOBIN IN A CELL AND/OR MAMMAL
Abstract:
In embodiments of the invention, the invention provides a method of increasing the amount of fetal hemoglobin or decreasing the amount of adult hemoglobin in a cell. In other embodiments of the invention, the invention provides a method of preventing or treating sickle cell disease or a β-thalassemia in a mammal. In another embodiment of the invention, the invention provides plasmids encoding the protein LIN28A, the protein LIN28B, a let-7 sponge, or any combination thereof.