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1. (WO2014200441) CORE-SHELL FLUORESCENT UPCONVERSION NANOPARTICLES FOR PHOTOACTIVATION OF MULTIPLE BIOMOLECULES

Pub. No.:    WO/2014/200441    International Application No.:    PCT/SG2014/000281
Publication Date: Fri Dec 19 00:59:59 CET 2014 International Filing Date: Sat Jun 14 01:59:59 CEST 2014
IPC: G01N 33/53
B82Y 5/00
A61K 41/00
C09K 11/00
Applicants: NATIONAL UNIVERSITY OF SINGAPORE
Inventors: ZHANG, Yong
JAYAKUMAR, Muthu Kumara Gnanasammandhan
BANSAL, Akshaya
Title: CORE-SHELL FLUORESCENT UPCONVERSION NANOPARTICLES FOR PHOTOACTIVATION OF MULTIPLE BIOMOLECULES
Abstract:
The invention provides, inter alia, upconversion nanoparticles (UCN) configured for near infrared (NIR) light excitation and ultraviolet (UV) light emission, visible light emission, or UV and visible light emission and compositions containing them. The invention also provides methods of making and using these UCNs, e.g., for delivery and photoactivation of target compounds, imaging biological tissues, and methods of treatment, e.g., of cancers, such as melanoma, by delivering chemotherapeutic agents, such as taxanes.