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1. (WO2014200373) 3-CARBAMOYL-1 -METHYLPYRIDINIUM NITRITE, PROCESS FOR ITS PREPARATION AND ITS USE

Pub. No.:    WO/2014/200373    International Application No.:    PCT/PL2014/050036
Publication Date: Fri Dec 19 00:59:59 CET 2014 International Filing Date: Wed Jun 11 01:59:59 CEST 2014
IPC: C07D 213/82
A61K 31/455
A61P 9/10
A61P 7/02
A61P 3/00
A61P 9/12
Applicants: UNIWERSYTET JAGIELLOŃSKI
Inventors: CHŁOPICKI, Stefan
PERNAK, Juliusz
NIEMCZAK, Michał
KRAMKOWSKI, Karol
LESZCZYŃSKA, Agnieszka
WALCZAK, Maria
Title: 3-CARBAMOYL-1 -METHYLPYRIDINIUM NITRITE, PROCESS FOR ITS PREPARATION AND ITS USE
Abstract:
The invention relates to a novel pyridinium salt comprising an anion in the form of a nitrite and a cation in the form of a 3-carbamoyl-l -methylpyridinium, the process of its preparation and its use for the manufacture of a vascular protective agent for the treatment or prevention of conditions or diseases associated with the dysfunction of vascular endothelium, failure of endothelial synthesis of nitric oxide (NO) and/or failure of endothelial synthesis of prostacyclin (PGI2).