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1. WO2014200373 - 3-CARBAMOYL-1 -METHYLPYRIDINIUM NITRITE, PROCESS FOR ITS PREPARATION AND ITS USE

Publication Number WO/2014/200373
Publication Date 18.12.2014
International Application No. PCT/PL2014/050036
International Filing Date 10.06.2014
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78
Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
81
Amides; Imides
82
in position 3
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
455
Nicotinic acid, i.e. niacin; Derivatives thereof, e.g. esters, amides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
10
for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7
Drugs for disorders of the blood or the extracellular fluid
02
Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
12
Antihypertensives
C07D 213/82 (2006.01)
A61K 31/455 (2006.01)
A61P 9/10 (2006.01)
A61P 7/02 (2006.01)
A61P 3/00 (2006.01)
A61P 9/12 (2006.01)
CPC
C07D 213/82
Applicants
  • UNIWERSYTET JAGIELLOŃSKI [PL/PL]; Kraków 24 ul. Gołębia PL-31-007 Kraków, PL
Inventors
  • CHŁOPICKI, Stefan; PL
  • PERNAK, Juliusz; PL
  • NIEMCZAK, Michał; PL
  • KRAMKOWSKI, Karol; PL
  • LESZCZYŃSKA, Agnieszka; PL
  • WALCZAK, Maria; PL
Agents
  • CZARNIK, Maciej; Bobrzynskiego 14 PL-30-348 Kraków, PL
Priority Data
P.40427311.06.2013PL
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 3-CARBAMOYL-1 -METHYLPYRIDINIUM NITRITE, PROCESS FOR ITS PREPARATION AND ITS USE
(FR) NITRITE DE 3-CARBAMOYL-1-MÉTHYLPYRIDINIUM, PROCÉDÉ POUR SA PRÉPARATION ET SON UTILISATION
Abstract
(EN)
The invention relates to a novel pyridinium salt comprising an anion in the form of a nitrite and a cation in the form of a 3-carbamoyl-l -methylpyridinium, the process of its preparation and its use for the manufacture of a vascular protective agent for the treatment or prevention of conditions or diseases associated with the dysfunction of vascular endothelium, failure of endothelial synthesis of nitric oxide (NO) and/or failure of endothelial synthesis of prostacyclin (PGI2).
(FR)
La présente invention concerne un nouveau sel de pyridinium comprenant un anion sous la forme d'un nitrite et un cation sous la forme d'un 3-carbamoyl-1-méthylpyridinium, le procédé pour sa préparation et son utilisation dans la production d'un agent protecteur vasculaire pour le traitement ou la prévention d'états pathologiques ou de maladies associés au dysfonctionnement de l'endothélium vasculaire, un défaut de synthèse endothéliale de l'oxyde nitrique (NO) et/ou un défaut de synthèse endothéliale de la prostacycline (PGI2).
Also published as
Latest bibliographic data on file with the International Bureau