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1. (WO2014199960) GLYCINE TRANSPORTER INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/199960    International Application No.:    PCT/JP2014/065269
Publication Date: 18.12.2014 International Filing Date: 09.06.2014
IPC:
C07C 233/73 (2006.01), A61K 31/166 (2006.01), A61K 31/277 (2006.01), A61K 31/415 (2006.01), A61K 31/44 (2006.01), A61K 31/4439 (2006.01), A61K 31/444 (2006.01), A61K 31/4725 (2006.01), A61K 31/497 (2006.01), A61K 31/505 (2006.01), A61K 31/506 (2006.01), A61P 1/00 (2006.01), A61P 21/00 (2006.01), A61P 25/14 (2006.01), A61P 25/16 (2006.01), A61P 25/18 (2006.01), A61P 25/20 (2006.01), A61P 25/22 (2006.01), A61P 25/24 (2006.01), A61P 25/28 (2006.01), A61P 25/30 (2006.01), A61P 29/00 (2006.01), A61P 43/00 (2006.01), C07C 233/76 (2006.01), C07C 235/48 (2006.01), C07C 255/60 (2006.01), C07D 213/40 (2006.01), C07D 213/81 (2006.01), C07D 231/12 (2006.01), C07D 239/26 (2006.01), C07D 401/04 (2006.01), C07D 401/12 (2006.01), C07D 403/12 (2006.01), C07D 471/04 (2006.01), C07D 498/04 (2006.01)
Applicants: TAISHO PHARMACEUTICAL CO., LTD. [JP/JP]; 24-1, Takada 3-chome, Toshima-ku, Tokyo 1708633 (JP)
Inventors: YAMADA, Yousuke; (JP).
OHTA, Hiroshi; (JP).
TAMITA, Tomoko; (JP).
ABE, Kumi; (JP).
YAMAMOTO, Shuji; (JP).
SHIROKAWA, Shin-ichi; (JP).
ABE, Masahito; (JP).
MATSUDA, Yohei; (JP).
ARAKI, Yuko; (JP)
Agent: ONO, SHINJIRO; YUASA AND HARA, Section 206, New Ohtemachi Bldg., 2-1, Ohtemachi 2-chome, Chiyoda-ku, Tokyo 1000004 (JP)
Priority Data:
2013-122243 10.06.2013 JP
Title (EN) GLYCINE TRANSPORTER INHIBITOR
(FR) INHIBITEUR DE TRANSPORTEUR DE GLYCINE
(JA) グリシントランスポーター阻害物質
Abstract: front page image
(EN)The present invention provides a novel compound represented by formula (IA) or a pharmaceutically acceptable salt thereof, which is useful for prophylaxis or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, a specific phobia, acute stress disorder and the like), depression, drug dependence, convulsion, tremor, pain, Parkinson's disease, attention deficit hyperactivity disorder, bipolar disorder, eating disorder and sleep disorder, on the basis of an inhibitory activity on glycine uptake.
(FR)La présente invention concerne un nouveau composé représenté par la formule (IA) ou un sel associé pharmaceutiquement acceptable, qui est utile pour la prophylaxie ou le traitement de maladies telles que la schizophrénie, la maladie d'Alzheimer, un trouble cognitif, la démence, des troubles anxieux (un trouble anxieux généralisé, un trouble panique, un trouble obsessionnel-compulsif, un trouble d'anxiété sociale, un trouble de stress post-traumatique, une phobie spécifique, un trouble de stress aigu et analogues), la dépression, une pharmacodépendance, la convulsion, le tremblement, la douleur, la maladie de Parkinson, un trouble déficitaire de l'attention avec hyperactivité, un trouble bipolaire, un trouble de l'alimentation et un trouble du sommeil, sur la base d'une activité inhibitrice de la capture de glycine.
(JA)本発明は、グリシン取り込み阻害作用に基づいた統合失調症、アルツハイマー病、認知機能障害、認知症、不安障害(全般性不安障害、パニック障害、強迫性障害、社会不安障害、外傷後ストレス障害、特定の恐怖症、急性ストレス障害等)、うつ病、薬物依存、痙攣、振戦、疼痛、パーキンソン病、注意欠陥・多動性障害、双極性障害、摂食障害、又は睡眠障害等の疾患の予防又は治療に有用な新規な下記式[IA]の化合物又はその医薬上許容される塩を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)