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1. (WO2014199401) PROCESS FOR CABAZITAXEL

Pub. No.:    WO/2014/199401    International Application No.:    PCT/IN2014/000395
Publication Date: Fri Dec 19 00:59:59 CET 2014 International Filing Date: Fri Jun 13 01:59:59 CEST 2014
IPC: C07D 305/00
Applicants: HETERO RESEARCH FOUNDATION
PARTHASARADHI REDDY, Bandi
RATHNAKAR REDDY, Kura
MURALIDHARA REDDY, Dasari
VENKAT NARSIMHA REDDY, Adulla
VAMSI KRISHNA, Bandi
Inventors: PARTHASARADHI REDDY, Bandi
RATHNAKAR REDDY, Kura
MURALIDHARA REDDY, Dasari
VENKAT NARSIMHA REDDY, Adulla
VAMSI KRISHNA, Bandi
Title: PROCESS FOR CABAZITAXEL
Abstract:
This invention discloses the method of preparation of 4alfa.acetoxy-2alfa-benzoyloxy-5beta,20-epoxy-1beta,13alfa-dihydroxy-7beta, 10beta-dimethoxy-9-oxo-11-taxen (7beta, 10beta-dimethoxy-10-deacetoxybaccatin III) and the preparation of cabazitaxel, which comprises: a. dissolving (2aR,4S,4aS,6R,9S, 11S.I2S, 12aR, 12bS)-12b-acetoxy-9- (( (2R,3 S)-3-amino-2-hydroxy-3-phenylpropanoyl)oxy)-1 I-hydroxy-4,6-dimethoxy-4a,8, 13, 13-tettamethyl-5-oxo-2a, 3,4,4a, 5,6,9, 10, 1 1,12, 12a, 12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[l,2-b]oxet-12-yl benzoate.