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1. (WO2014198989) FIBRIN HYDROGELS COMPRISING PLASMONIC NANOPARTICLES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/198989 International Application No.: PCT/ES2014/070484
Publication Date: 18.12.2014 International Filing Date: 11.06.2014
IPC:
A61K 9/51 (2006.01) ,A61K 33/34 (2006.01) ,A61P 35/00 (2006.01) ,A61P 17/02 (2006.01) ,A61P 29/00 (2006.01) ,A61P 31/00 (2006.01) ,B82Y 5/00 (2011.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
34
Copper; Compounds thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
02
for treating wounds, ulcers, burns, scars, keloids, or the like
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
B PERFORMING OPERATIONS; TRANSPORTING
82
NANO-TECHNOLOGY
Y
SPECIFIC USES OR APPLICATIONS OF NANO-STRUCTURES; MEASUREMENT OR ANALYSIS OF NANO-STRUCTURES; MANUFACTURE  OR TREATMENT OF NANO-STRUCTURES
5
Nano-biotechnology or nano-medicine, e.g. protein engineering or drug delivery
Applicants: FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ[ES/ES]; Paseo de la Castellana, 261 Edificio Norte (Antigua Escuela de Enfermeras) 4ª Planta E-28046 Madrid, ES
CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED EN BIOINGENIERÍA, BIOMATERIALES Y NANOMEDICINA (CIBER-BBN)[ES/ES]; C/ Poeta Mariano Esquillor s/n Campus Río Ebro Edificio I+D, Bloque 5 Planta 1ª E-50018 Zaragoza, ES
UNIVERSIDAD DE ZARAGOZA[ES/ES]; Calle Pedro Cerbuna, 12. Campus Plz San Fº Edificio Interfacultades, 1ª planta. E-50009 Zaragoza, ES
Inventors: MARTÍN SAAVEDRA, Francisco Manuel; ES
VILABOA DÍAZ, Nuria Elda; ES
CEBRIÁN HERNANDO, Virginia; ES
ARRUEBO GORDO, Manuel; ES
SANTAMARÍA RAMIRO, Jesús; ES
GÓMEZ NAVASCUÉS, Leyre; ES
Priority Data:
P20133089414.06.2013ES
Title (EN) FIBRIN HYDROGELS COMPRISING PLASMONIC NANOPARTICLES
(FR) HYDROGELS DE FIBRINE À NANOPARTICULES PLASMONIQUES
(ES) HIDROGELES DE FIBRINA CON NANOPARTÍCULAS PLASMÓNICAS
Abstract:
(EN) The invention relates to a photothermal composition comprising a fibrin hydrogel matrix or a mixture of the precursors thereof, thrombin and fibrinogen, in which hydrogel plasmonic nanoparticles and heat-sensitive effectors are embedded, said effectors containing therapeutic agents that are released by applying electromagnetic radiation of a determined intensity and wavelength to the composition. The photothermal composition is suitable for generating hyperthermia in biological tissues in which said composition is implanted. The invention therefore also relates to the use of the composition for the destruction of tumours, the treatment of infections or the regeneration of tissues, as well as for the controlled administration of therapeutic agents.
(FR) La présente invention concerne une composition photothermique qui comprend une matrice d'hydrogel de fibrine ou un mélange de ses précurseurs, la thrombine et le fibrinogène, dans laquelle sont intégrées des nanoparticules plasmoniques et des effecteurs thermosensibles qui contiennent des agents thérapeutiques qui sont libérés après application, sur la composition, d'un rayonnement électromagnétique d'une intensité et longueur d'onde déterminées. Cette composition photothermique est utile pour générer une hyperthermie dans des tissus biologiques dans lesquels elle est implantée, la présente invention concernant également l'utilisation de cette composition pour la destruction de tumeurs, le traitement d'infections ou la régénération de tissus, ainsi que pour l'administration contrôlée d'agents thérapeutiques.
(ES) La presente invención se refiere a una composición fototérmica que comprende una matriz de hidrogel de fibrina o una mezcla de sus precursores, trombina y fibrinógeno, en la que se encuentran embebidas nanopartículas plasmónicas y efectores termosensibles que contienen agentes terapéuticos que son liberados tras aplicar a la composición radiación electromagnética de una determinada intensidad y longitud de onda. Esta composición fototérmica es útil para generar hipertermia en tejidos biológicos en los que se implanta, por lo que la presente invención también se refiere al uso de esta composición para la destrucción de tumores, el tratamiento de infecciones o la regeneración de tejidos, así como para la administración controlada de agentes terapéuticos.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)