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1. (WO2014198911) IMPROVED POLYNUCLEOTIDE SEQUENCES ENCODING TALE REPEATS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/198911 International Application No.: PCT/EP2014/062405
Publication Date: 18.12.2014 International Filing Date: 13.06.2014
IPC:
C12N 15/63 (2006.01) ,C12N 15/86 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
Applicants:
CELLECTIS [FR/FR]; 8 rue de la Croix Jarry F-75013 Paris, FR
Inventors:
DUCHATEAU, Philippe; FR
ARNOULD, Sylvain; FR
SMITH, Julianne; FR
Agent:
ZACCO DENMARK A/S; Arne Jacobsens Allé 15 DK-2300 Copenhagen S, DK
Priority Data:
PA 2013 7032114.06.2013DK
Title (EN) IMPROVED POLYNUCLEOTIDE SEQUENCES ENCODING TALE REPEATS
(FR) SÉQUENCES POLYNUCLÉOTIDIQUES AMÉLIORÉES CODANT DES RÉPÉTITIONS DE PROTÉINES TALE
Abstract:
(EN) The present invention is in the field of the gene editing molecular tools. The present invention relates to rewritten nucleic acid sequences encoding repeated DNA recognition motifs of TALE (Transcription Activator-Like Effector) proteins. These nucleic acid sequences allow assembly and cloning of TALE repeats in any type of vectors, especially viral vectors. The invention thereby contributes to improving gene targeting in cells using TALE derived proteins, in particular for genetic regulation or modification. The present invention is particularly drawn to virus mediated transformation methods, by providing vectors, compositions and kits including said new nucleic acid sequences.
(FR) L'invention a trait au domaines des outils moléculaires de manipulation de gènes. L'invention concerne en particulier des séquences d'acides nucléiques réécrites codant des motifs de reconnaissance d'ADN répétés des protéines TALE (Transcription Activator-Like Effector). Ces séquences d'acides nucléiques permettent l'assemblage et le clonage de répétitions de TALE dans n'importe quel type de vecteurs, en particulier des vecteurs viraux. La présente invention contribue ainsi à l'amélioration du ciblage de gènes dans des cellules au moyen de protéines issues de TALE, notamment dans la régulation ou la modification génétique. L'invention concerne en particulier des procédés de transformation induite par virus mettant en oeuvre des vecteurs, des compostions et des kits contenant ces nouvelles séquences d'acides nucléiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)