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1. (WO2014198909) RAC1 INHIBITORS FOR INDUCING BRONCHODILATION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/198909 International Application No.: PCT/EP2014/062402
Publication Date: 18.12.2014 International Filing Date: 13.06.2014
IPC:
A61K 31/496 (2006.01) ,A61K 45/00 (2006.01) ,A61P 11/06 (2006.01) ,A61P 11/08 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496
Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
06
Antiasthmatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11
Drugs for disorders of the respiratory system
08
Bronchodilators
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)[FR/FR]; 101, rue de Tolbiac F-75013 Paris, FR
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)[FR/FR]; 3, Rue Michel Ange F-75016 Paris, FR
UNIVERSITÉ DE NANTES[FR/FR]; 1, quai de Tourville F-44000 Nantes, FR
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES[FR/FR]; 5 Allée de l'Ile Gloriette F-44093 Nantes Cedex, FR
Inventors: SAUZEAU, Vincent; FR
ANDRE, Gwennan; FR
LOIRAND, Gervaise; FR
MAGNAN, Antoine; FR
LAIR, David; FR
Agent: HIRSCH, Denise; FR
Priority Data:
13305808.114.06.2013EP
Title (EN) RAC1 INHIBITORS FOR INDUCING BRONCHODILATION
(FR) INHIBITEURS DE RAC1 DESTINÉS À INDUIRE LA BROCHODILATATION
Abstract:
(EN) The invention relates to a Rac1 inhibitor for use as bronchodilator in a patient in need thereof. The invention provides a Rac1 inhibitor for use in a method for inducing bronchodilation in a patient in need thereof. The invention also relates to a Rac1 inhibitor for use in a method for reducing AHR in a patient in need thereof.
(FR) La présente invention concerne un inhibiteur de Rac1 pour son utilisation en tant que bronchodilatateur chez un patient le nécessitant. L'invention concerne un inhibiteur de Rac1 pour son utilisation dans un procédé d'induction de la bronchodilatation chez un patient le nécessitant. L'invention concerne également un inhibiteur de Rac1 pour son utilisation dans un procédé de réduction de l'hypersensibilité des voies respiratoires (AHR) chez un patient le nécessitant.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)