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1. WO2014198849 - ANTIBACTERIAL THIAZOLECARBOXYLIC ACIDS

Publication Number WO/2014/198849
Publication Date 18.12.2014
International Application No. PCT/EP2014/062281
International Filing Date 12.06.2014
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
56
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
C07D 277/56 (2006.01)
A61K 31/426 (2006.01)
A61P 31/00 (2006.01)
CPC
A61K 31/426
A61K 31/427
A61K 31/4439
A61K 31/454
A61K 31/4545
A61K 31/4709
Applicants
  • ANTABIO SAS [FR/FR]; Biostep, 436 rue Pierre et Marie Curie F-31670 Labege, FR
Inventors
  • LEMONNIER, Marc; FR
  • DAVIES, David; FR
  • PALLIN, Thomas David; GB
Agents
  • SIMONS, Amanda Louise; GB
Priority Data
1310542.413.06.2013GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBACTERIAL THIAZOLECARBOXYLIC ACIDS
(FR) ACIDES THIAZOLE CARBOXYLIQUES ANTIBACTÉRIENS
Abstract
(EN)
Compounds of general formula (I), wherein R1, R11, Y, R2, n and A are as defined herein are useful as inhibitors or metallo-β-lactamase (MBL) enzymes and can be used for reducing or removing antibiotic resistance in bacteria.
(FR)
Les composés de formule générale (I), dans laquelle R1, R11, Y, R2, n et A sont tels que définis dans la description sont utiles en tant qu'inhibiteurs ou enzymes métallo-beta-lactamases (MBL) et peuvent être utilisés pour réduire ou supprimer la résistance aux antibiotiques dans des bactéries.
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