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1. (WO2014198620) MACROCYCLIC UREA DERIVATIVES AS INHIBITORS OF TAFIA, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS

Pub. No.:    WO/2014/198620    International Application No.:    PCT/EP2014/061669
Publication Date: Fri Dec 19 00:59:59 CET 2014 International Filing Date: Fri Jun 06 01:59:59 CEST 2014
IPC: C07D 413/12
C07D 273/01
A61K 31/553
A61P 7/00
Applicants: SANOFI
Inventors: EVERS, Andreas
KALLUS, Christopher
WAGNER, Michael
WEHLAN, Hermut
Title: MACROCYCLIC UREA DERIVATIVES AS INHIBITORS OF TAFIA, THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
Abstract:
The present invention relates to macrocydic urea derivatives of the formula I (I) in which R1, R2, R3, V and Y are as defined below. The compounds of the formula I are inhibitors of the enzyme TAFIa (activated thrombin-activatable fibrinolysis inhibitor). The invention further relates to the process for the preparation of the compounds of formula I and to the use thereof as medicaments.