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Machine translation
1. (WO2014198606) COHESIVE LIQUID BOLUS COMPRISING BIOACTIVES
Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

CLAIMS

1. A bolus selected from a cohesive liquid having

(i) a shear viscosity of less than about 400 mPas, and

(ii) a relaxation time, determined by a Capillary Breakup Extensional heometry (CaBER) experiment, of more than 10 ms (milliseconds) at a temperature of 20°C;

bolus comprising:

(1) an aqueous solution of at least one food grade biopolymer selected from the group consisting of botanical hydrocolloids, microbial hydrocolloids, animal hydrocolloids, algae hydrocolloids and any combination thereof;

(2) at least one bioactive compound selected from:

(a) Anabolic compounds;

(b) Anti-catabolic compounds;

(c) Cell function or neuromuscular junction stimulating compounds; and

(d) Cell energy metabolism stimulating compounds.

2. The bolus according to claim 1, wherein

(a) The anabolic compounds are optionally selected from the group consisting of leucine, leucine metabolites, a-hydroxyisocaproic acid (HICA), glutamine, arginine, citrulline, creatine, whey, medium chain fatty acids (MCFA) and combinations thereof;

(b) The anti-catabolic compounds are optionally selected from the group consisting of polyunsaturated fatty acids (PUFA), ω-3 fatty acids, carnitine, creatine, and combinations thereof;

(c) The cell function or neuromuscular junction stimulating compounds are optionally selected from the group consisting of choline, vitamin D, creatine,

Oleoylethanolamide (OEA), resveratrol, and combinations thereof;

(d) The cell energy metabolism stimulating compounds are optionally selected from the group consisting of antioxidants, coenzyme Q10, creatine, lipoic acid, carnitine, resveratrol, medium chain fatty acids (MCFA) and combinations thereof.

3. The bolus according to claim 1 or 2, wherein the bolus is selected from a cohesive thin liquid having

(i) a shear viscosity of less than about 50 mPas, preferably from 5 to 45 mPas, more preferably from 10 to 40 mPas, and most preferably from 20 to 30 mPas, when measured at a shear rate of 50 s-1;

and

(ii) a relaxation time, determined by a Capillary Breakup Extensional heometry (CaBER) experiment, of more than 10 ms (milliseconds) at a temperature of 20°C.

4. The bolus according to claim 1 or 2, wherein the bolus is selected from a cohesive thickened liquid having

(i) a shear viscosity of more than about 50mPas, preferably from 55 to 350 mPas, more preferably from 60 to 200 mPas, and most preferably from 70 to 100 mPas, when measured at a shear rate of 50 s-1;

and

(ii) a relaxation time, determined by a Capillary Breakup Extensional Rheometry (CaBER) experiment, of more than 10 ms (milliseconds) at a temperature of 20°C.

5. The bolus according to any one of the preceding claims, wherein the relaxation time is less than about 2000 ms, preferably from about 20 ms to about 1000 ms, more preferably from about 50 ms to about 500 ms, and most preferably from about 100 ms to about 200 ms, at a temperature of 20°C.

6. The bolus according to any one of the preceding claims, wherein the filament diameter of the bolus decreases less than linearly, and preferably exponentially in time during a CaBER experiment.

7. The bolus according to any one of the preceding claims, wherein the aqueous solution comprises the at least one food grade biopolymer in a concentration of from at least 0.01 wt% to 25 wt%, preferably from at least 0.1 wt% to 15 wt%, and most preferably from at least 1 wt% to 10 wt%.

8. The bolus according to any one of the preceding claims, wherein the food grade biopolymer is a botanical hydrocolloid selected from plant-extracted gums, plant-derived mucilages, or combinations thereof, wherein, optionally,

the plant-extracted gums are selected from the group consisting of okra gum, konjac mannan, tara gum, locust bean gum, guar gum, fenugreek gum, tamarind gum, cassia gum, acacia gum, gum ghatti, pectins, modified celluloses (e.g., carboxymethyl cellulose, methyl cellulose, hydroxylpropyl methyl cellulose, hydroxypropyl cellulose), tragacanth gum, karaya gum, or any combinations thereof, and preferably the plant-extracted gum is okra gum; and/or

the plant-derived mucilages are selected from the group consisting of kiwi fruit mucilage, cactus mucilage, chia seed mucilage, psyllium mucilage, mallow mucilage, flax seed mucilage, marshmallow mucilage, ribwort mucilage, mullein mucilage, cetraria mucilage, or combinations thereof, and preferably the plant-derived mucilage is kiwi fruit mucilage and/or cactus mucilage.

9. The bolus according to any one of the preceding claims in administrable form selected from the group consisting of a pharmaceutical formulation, a nutritional formulation, a nutritional supplement, a dietary supplement, a functional food, a beverage product, a full meal, a nutritionally complete formula, and combinations thereof.

10. The bolus according to any one of the preceding claims, for use in treating a swallowing disorder, for use in promoting safe swallowing of nutritional products, and/or for use in mitigating the risks of aspiration during swallowing of nutritional products in a patient in need of same.

11. The bolus according to any one of claims 1 to 9, for use in supporting, maintaining and/or improving strength and/or muscle health in a patient suffering from a swallowing disorder.

12. A method for making a bolus selected from a cohesive liquid, the method comprising steps of:

(1) Providing an aqueous solution of at least one food grade biopolymer capable of providing to the bolus:

(i) a shear viscosity of less than about 400 mPas, and

(ii) a relaxation time, determined by a Capillary Breakup Extensional heometry (CaBER) experiment, of more than 10 ms (milliseconds) at a temperature of 20°C;

Adding to said aqueous solution at least one bioactive compound

Anabolic compounds;

Anti-catabolic compounds;

Cell function or neuromuscular junction stimulating compounds; and Cell energy metabolism stimulating compounds.

13. The method according to claim 12, wherein

(a) The anabolic compounds are optionally selected from the group consisting of leucine, leucine metabolites, a-hydroxyisocaproic acid (HICA), glutamine, arginine, citrulline, creatine, whey, medium chain fatty acids (MCFA) and combinations thereof;

(b) The anti-catabolic compounds are optionally selected from the group consisting of polyunsaturated fatty acids (PUFA), ω-3 fatty acids, carnitine, creatine, and combinations thereof;

(c) The cell function or neuromuscular junction stimulating compounds are optionally selected from the group consisting of choline, vitamin D, creatine,

Oleoylethanolamide (OEA), resveratrol, and combinations thereof; and/or

(d) The cell energy metabolism stimulating compounds are optionally selected from the group consisting of antioxidants, coenzyme Q10, creatine, lipoic acid, carnitine, resveratrol, medium chain fatty acids (MCFA) and combinations thereof.

14. The method according to claim 12 or 13, wherein the bolus is selected from a cohesive thin liquid, and wherein in step (1) an aqueous solution of at least one food grade biopolymer is provided which is capable of providing to the bolus:

(i) a shear viscosity of less than about 50 mPas, preferably from 5 to 45 mPas, more preferably from 10 to 40 mPas, and most preferably from 20 to 30 mPas, when measured at a shear rate of 50 s-1, and

(ii) a relaxation time, determined by a Capillary Breakup Extensional heometry (CaBER) experiment, of more than 10 ms (milliseconds) at a temperature of 20°C.

15. The method according to claim 12 or 13, wherein the bolus is selected from a cohesive thickened liquid, and wherein in step (1) an aqueous solution of at least one food grade biopolymer is provided which is capable of providing to the bolus:

(i) a shear viscosity of more than about 50mPas, preferably from 55 to 350 mPas, more preferably from 60 to 200 mPas, and most preferably from 70 to 100 mPas, when measured at a shear rate of 50 s-1, and

(ii) a relaxation time, determined by a Capillary Breakup Extensional Rheometry (CaBER) experiment, of more than 10 ms (milliseconds) at a temperature of 20°C.