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1. (WO2014198478) BIFUNCTIONAL CHELATING AGENTS BASED ON THE 1,4-DIAZEPINE SCAFFOLD (DAZA) FOR NON-INVASIVE MOLECULAR IMAGING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/198478    International Application No.:    PCT/EP2014/059874
Publication Date: 18.12.2014 International Filing Date: 14.05.2014
IPC:
A61K 51/04 (2006.01)
Applicants: JOHANNES GUTENBERG-UNIVERSITÄT MAINZ [DE/DE]; Saarstrasse 21 55122 Mainz (DE)
Inventors: RÖSCH, Frank; (DE).
WALDRON, Bradley Peter; (DE).
PARKER, David; (GB)
Agent: PLATE SCHWEITZER ZOUNEK PAE; Rheingaustrasse 196 Industriepark Kalle-Albert, Geb. H 391 65203 Wiesbaden (DE)
Priority Data:
10 2013 106 066.8 11.06.2013 DE
Title (EN) BIFUNCTIONAL CHELATING AGENTS BASED ON THE 1,4-DIAZEPINE SCAFFOLD (DAZA) FOR NON-INVASIVE MOLECULAR IMAGING
(FR) AGENTS CHÉLATEURS BIFONCTIONNELS À BASE DE L'ÉCHAFAUDAGE 1,4-DIAZÉPINE (DAZA) POUR L'IMAGERIE MOLÉCULAIRE NON INVASIVE
Abstract: front page image
(EN)A compound for radio metal complexation comprises a chelator and one or more biological targeting vectors TV conjugated to said chelator, wherein the chelator has structure (A) or (B) or (C), based on 1,4-diazepine with groups R1; R2, R3, R4, X1, X2, X3. The compound is particularly suited for complexation of radio-isotopic metals, such as 66Ga(III), 67Ga(III) and 68Ga(III).
(FR)L'invention concerne un composé pour la complexation métallique radio, qui comprend un chélateur et un ou plusieurs vecteurs de ciblage biologiques TV conjugués audit chélateur, le chélateur ayant une structure (A), (B) ou (C) à base de 1,4-diazépine avec des groupes R1; R2, R3, R4, X1, X2, X3. Le composé est particulièrement approprié pour la complexation de métaux radio-isotopes, tels que 66Ga(III), 67Ga(III) et 68Ga(III).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)