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1. (WO2014198330) COMBINATION OF CD37 ANTIBODIES WITH CHLORAMBUCIL

Pub. No.:    WO/2014/198330    International Application No.:    PCT/EP2013/062365
Publication Date: Fri Dec 19 00:59:59 CET 2014 International Filing Date: Sat Jun 15 01:59:59 CEST 2013
IPC: C07K 16/28
A61K 31/195
Applicants: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Inventors: HEIDER, Karl-Heinz
BLUM, Petra
Title: COMBINATION OF CD37 ANTIBODIES WITH CHLORAMBUCIL
Abstract:
The present invention relates to immunotherapies that are based on depletion of CD37- positive cells such as B-cells. The present invention provides methods for reduction of CD37-positive cells such as B-cells in an individual/ patient using a combination of CD37 antibody /antibodies and chlorambucil. The combination of CD37 antibodies and chlorambucilis shown to have a synergistic effect. The application further provides materials and methods for treatment of diseases involving aberrant B-cell activity.