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1. (WO2014197936) BIOMARKERS AND USE THEREOF IN IDENTIFICATION OF B-CELL LYMPHOPROLIFERATIVE DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2014/197936    International Application No.:    PCT/AU2014/000610
Publication Date: 18.12.2014 International Filing Date: 13.06.2014
IPC:
C12Q 1/68 (2006.01)
Applicants: THE STATE OF QUEENSLAND ACTING THROUGH ITS DEPARTMENT OF HEALTH [AU/AU]; Queensland Health Building 147-163 Charlotte Street Brisbane, Queensland 4000 (AU)
Inventors: GHANDI, Maher; (AU)
Agent: FISHER ADAMS KELLY; Level 6, 175 Eagle Street Brisbane, QLD 4000 (AU)
Priority Data:
2013902216 14.06.2013 AU
Title (EN) BIOMARKERS AND USE THEREOF IN IDENTIFICATION OF B-CELL LYMPHOPROLIFERATIVE DISORDERS
(FR) BIOMARQUEURS ET LEUR UTILISATION EN IDENTIFICATION DE TROUBLES LYMPHOPROLIFERATIFS B
Abstract: front page image
(EN)A method of determining whether or not a subject has a B-cell lymphproliferative disorder, includes determining the expression, level of one or more of miRNA.-l.973., rni.RNA.-638 and tmRNA-494, wherein a B-cell lymphoproiiferative disorder is associated with elevated levels of the miRNAs. Measurement of expression levels of these miRNAs may he useful in a method of evaluating treatment eftlcacy of a B-cell lymphproliferative disorder, a method of treating a B-cell lymphoproliferative disorder and/or a method of determining the prognosis of a subject with a B-cell lymphoproliferative disorder. Examples of B-cell lymphproliferative disorders include Diffuse large B-cell lymphoma, follicular lymphoma, chronic lymphocytic leukemia, mantle cell lymphoma, classical Hodgkin Lymphoma and Burkitt lymphoma.
(FR)L'invention porte sur un procédé permettant de déterminer si un sujet a ou non un trouble lymphoprolifératif B, comprenant la détermination du taux d'expression d'un ou plusieurs miARN choisis parmi miARN-l.973, miARN-638 et tmARN-494, un trouble lymphoprolifératif B étant associé à des taux élevés des miARN. La mesure des taux d'expression de ces miARN peut être utile dans un procédé d'évaluation de l'efficacité de traitement d'un trouble lymphoprolifératif B, un procédé de traitement d'un trouble lymphoprolifératif B et/ou un procédé de détermination du pronostic d'un sujet atteint d'un trouble lymphoprolifératif B. Les exemples de troubles lymphoprolifératifs B comprennent le lymphome B diffus à grandes cellules, le lymphome folliculaire, la leucémie lymphoïde chronique, le lymphome à cellules du manteau, le lymphome hodgkinien classique et le lymphome de Burkitt.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)