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1. (WO2014197860) METHOD OF MAKING MONOMETHYL FUMARATE

Pub. No.:    WO/2014/197860    International Application No.:    PCT/US2014/041406
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Sat Jun 07 01:59:59 CEST 2014
IPC: C07C 67/08
C07C 67/333
C07D 295/185
C07C 231/12
Applicants: XENOPORT, INC.
Inventors: RAILLARD, Stephen P.
SCHEUERMAN, Randall A.
MANTHATI, Suresh K.
Title: METHOD OF MAKING MONOMETHYL FUMARATE
Abstract:
Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis.