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1. (WO2014197714) PHOSPHORAMIDITE BUILDING BLOCKS FOR SUGAR-CONJUGATED OLIGONUCLEOTIDES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/197714 International Application No.: PCT/US2014/041133
Publication Date: 11.12.2014 International Filing Date: 05.06.2014
IPC:
C07H 21/00 (2006.01)
Applicants: AM CHEMICALS LLC[US/US]; 4065 Oceanside Blvd., Suite M Oceanside, CA 92056-5824, US
Inventors: GUZAEV, Andrei, Pavel; US
VVEDENSKIY, Vladimir, Y.; US
Agent: REITER, Stephen, E.; Kilpatrick Townsend & Stockton LLP Two Embarcadero Center, Eighth Floor San Francisco, CA 94111, US
Priority Data:
61/831,52105.06.2013US
Title (EN) PHOSPHORAMIDITE BUILDING BLOCKS FOR SUGAR-CONJUGATED OLIGONUCLEOTIDES
(FR) BLOCS DE CONSTRUCTION À BASE DE PHOSPHORAMIDITE POUR OLIGONUCLÉOTIDES CONJUGUÉS À DES SUCRES
Abstract:
(EN) Novel nucleoside phosphoramidite building blocks for preparation of synthetic oligonucleotides containing at least one phosphotriester linkage conjugated to a monosaccharide and synthetic processes for making the same are disclosed. Furthermore, oligomeric compounds are prepared using said building blocks, preferably followed by removal of protecting groups to provide monosaccharide-conjugated oligonucleotides.
(FR) La présente invention concerne de nouveaux blocs de construction nucléosidiques à base de phosphoramidite permettant la préparation d'oligonucléotides de synthèse contenant au moins une liaison phosphotriester conjuguée à un monosaccharide, ainsi que des procédés de synthèse permettant leur production. L'invention concerne, en outre, des composés oligomères préparés à partir desdits blocs de construction, ladite préparation étant, de préférence, suivie de l'élimination des groupes protecteurs en vue de l'obtention d'oligonucléotides conjugués à des monosaccharides.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)