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1. (WO2014197578) 1',4'-THIO NUCLEOSIDES FOR THE TREATMENT OF HCV

Pub. No.:    WO/2014/197578    International Application No.:    PCT/US2014/040884
Publication Date: Fri Dec 12 00:59:59 CET 2014 International Filing Date: Thu Jun 05 01:59:59 CEST 2014
IPC: C07H 19/067
A61K 31/7072
A61P 31/14
Applicants: IDENIX PHARMACEUTICALS, INC.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
UNIVERSITE DE MONTPELLIER
Inventors: DUKHAN, David
GOSSELIN, Gilles
DOUSSON, Cyril B.
Title: 1',4'-THIO NUCLEOSIDES FOR THE TREATMENT OF HCV
Abstract:
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 1',4'-thio nucleoside compounds which display remarkable efficacy and bioavailability for the treatment of, for example, HCV infection in a human. In certain embodiments, the compounds are of Formula 3001: (3001); or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof; wherein Base, RA, RB, W, X, Y, and Z are as described herein.