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1. (WO2014197543) ASSAYS, METHODS AND KITS FOR ANALYZING SENSITIVITY AND RESISTANCE TO ANTI-CANCER DRUGS, PREDICTING A CANCER PATIENT'S PROGNOSIS, AND PERSONALIZED TREATMENT STRATEGIES
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2014/197543 International Application No.: PCT/US2014/040806
Publication Date: 11.12.2014 International Filing Date: 04.06.2014
IPC:
C12Q 1/68 (2006.01) ,C12P 19/34 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19
Preparation of compounds containing saccharide radicals
26
Preparation of nitrogen-containing carbohydrates
28
N-glycosides
30
Nucleotides
34
Polynucleotides, e.g. nucleic acids, oligoribonucleotides
Applicants: UNIVERSITY OF MIAMI[US/US]; 1951 NW 7th Avenue, Suite 110 Miami, Florida 33136, US
Inventors: INCE, Tan A.; US
Agent: DOBBELAERE, Amy A.; Novak Druce Connolly Bove + Quigg LLP 525 Okeechobee Blvd. Fifteenth Floor West Palm Beach, Florida 33401, US
Priority Data:
61/830,70904.06.2013US
Title (EN) ASSAYS, METHODS AND KITS FOR ANALYZING SENSITIVITY AND RESISTANCE TO ANTI-CANCER DRUGS, PREDICTING A CANCER PATIENT'S PROGNOSIS, AND PERSONALIZED TREATMENT STRATEGIES
(FR) DOSAGES, PROCÉDÉS ET KITS D'ANALYSE DE LA SENSIBILITÉ ET DE LA RÉSISTANCE À DES MÉDICAMENTS ANTICANCÉREUX, DONNANT UN PRONOSTIC DE PATIENT CANCÉREUX, ET STRATÉGIES THÉRAPEUTIQUES PERSONNALISÉES
Abstract:
(EN) Described herein are assays, methods and kits for analyzing sensitivity of a subject's cancerous tumor to a drug, predicting responses of cancerous tumors to drugs, determining the prognosis of a subject having a cancerous tumor, and developing a personalized therapy or treatment strategy for the subject. The assays, methods and kits involve analyzing gene and protein expression signatures or profiles of a subject's cancerous tumor, testing candidate drugs in cancerous cells from the subject's cancerous tumor, and classifying a subject's cancerous tumor based on ovarian cell and fallopian tube cell cell-of-origin gene expression signatures. Using these methods, a suitable drug (or drugs) is identified, the subject can be treated with that drug, and a personalized therapy can be developed for the subject.
(FR) La présente invention concerne des dosages, des procédés et des kits permettant l'analyse de la sensibilité de la tumeur cancéreuse d'un patient à un médicament, la prédiction de réponses de tumeurs cancéreuses à des médicaments, la détermination du pronostic d'un patient présentant une tumeur cancéreuse et le développement d'un traitement ou d'une stratégie personnalisé(e) pour le patient. Les dosages, procédés et kits impliquent l'analyse des signatures de l'expression génique et protéique ou les profils de la tumeur cancéreuse d'un patient, les tests de médicaments candidats dans des cellules cancéreuses issues de la tumeur cancéreuse du patient et le classement d'une tumeur cancéreuse d'un patient sur la base des signatures d'expression génique des cellules d'origine des cellules ovariennes et des cellules de la trompe de Fallope. A l'aide de ces procédés, un médicament (ou des médicaments) approprié est identifié, le patient peut être traité avec ce médicament et un traitement personnalisé peut être mis au point pour le patient.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)